A (15;17) translocation not associated with acute promyelocytic leukaemia

Eros Di Bona, Anna Montaldi, Nicola Guercini, Vincenzo Rossi, Anna Luciano, Andrea Biondi, Francesco Rodeghiero

Research output: Contribution to journalArticlepeer-review

Abstract

We report a woman with acute myeloid leukaemia (AML) type M2 according to FAB classification, showing a t(15;17) apparently identical to that of acute promyelocytic leukaemia (APL) on conventional cytogenetic analysis. Fluorescence in situ hybridization (FISH) using cosmidic probes specific for RARα and PML regions did not show a fusion signal as in APL. The breakpoints were assigned to 15q24.3 and 17q21.1. Detailed molecular analyses did not reveal any involvement of RARα and PML genes. The patient was resistant to several front-line AML treatments and to all-trans retinoic acid (ATRA). These findings reinforce FISH and RT-PCR as useful tools for the characterization of a t(15;17) as the translocation specifically associated with APL.

Original languageEnglish
Pages (from-to)706-709
Number of pages4
JournalBritish Journal of Haematology
Volume95
Issue number4
Publication statusPublished - 1996

Keywords

  • acute myeloid leukaemia
  • acute promyelocytic leukaemia
  • chromosomal abnormality
  • fluorescence in situ hybridization
  • t(15;17) translocation

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'A (15;17) translocation not associated with acute promyelocytic leukaemia'. Together they form a unique fingerprint.

Cite this