A (15;17) translocation not associated with acute promyelocytic leukaemia

Eros Di Bona; Anna Montaldi; Nicola Guercini; Vincenzo Rossi; Anna Luciano; Andrea Biondi; Francesco Rodeghiero

A (15;17) translocation not associated with acute promyelocytic leukaemia

Eros Di Bona, Anna Montaldi, Nicola Guercini, Vincenzo Rossi, Anna Luciano, Andrea Biondi, Francesco Rodeghiero

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

We report a woman with acute myeloid leukaemia (AML) type M2 according to FAB classification, showing a t(15;17) apparently identical to that of acute promyelocytic leukaemia (APL) on conventional cytogenetic analysis. Fluorescence in situ hybridization (FISH) using cosmidic probes specific for RARα and PML regions did not show a fusion signal as in APL. The breakpoints were assigned to 15q24.3 and 17q21.1. Detailed molecular analyses did not reveal any involvement of RARα and PML genes. The patient was resistant to several front-line AML treatments and to all-trans retinoic acid (ATRA). These findings reinforce FISH and RT-PCR as useful tools for the characterization of a t(15;17) as the translocation specifically associated with APL.

Original language	English
Pages (from-to)	706-709
Number of pages	4
Journal	British Journal of Haematology
Volume	95
Issue number	4
Publication status	Published - 1996

Keywords

acute myeloid leukaemia
acute promyelocytic leukaemia
chromosomal abnormality
fluorescence in situ hybridization
t(15;17) translocation

ASJC Scopus subject areas

Hematology

Cite this

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title = "A (15;17) translocation not associated with acute promyelocytic leukaemia",

abstract = "We report a woman with acute myeloid leukaemia (AML) type M2 according to FAB classification, showing a t(15;17) apparently identical to that of acute promyelocytic leukaemia (APL) on conventional cytogenetic analysis. Fluorescence in situ hybridization (FISH) using cosmidic probes specific for RARα and PML regions did not show a fusion signal as in APL. The breakpoints were assigned to 15q24.3 and 17q21.1. Detailed molecular analyses did not reveal any involvement of RARα and PML genes. The patient was resistant to several front-line AML treatments and to all-trans retinoic acid (ATRA). These findings reinforce FISH and RT-PCR as useful tools for the characterization of a t(15;17) as the translocation specifically associated with APL.",

keywords = "acute myeloid leukaemia, acute promyelocytic leukaemia, chromosomal abnormality, fluorescence in situ hybridization, t(15;17) translocation",

author = "{Di Bona}, Eros and Anna Montaldi and Nicola Guercini and Vincenzo Rossi and Anna Luciano and Andrea Biondi and Francesco Rodeghiero",

year = "1996",

language = "English",

volume = "95",

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T1 - A (15;17) translocation not associated with acute promyelocytic leukaemia

AU - Di Bona, Eros

AU - Montaldi, Anna

AU - Guercini, Nicola

AU - Rossi, Vincenzo

AU - Luciano, Anna

AU - Biondi, Andrea

AU - Rodeghiero, Francesco

PY - 1996

Y1 - 1996

N2 - We report a woman with acute myeloid leukaemia (AML) type M2 according to FAB classification, showing a t(15;17) apparently identical to that of acute promyelocytic leukaemia (APL) on conventional cytogenetic analysis. Fluorescence in situ hybridization (FISH) using cosmidic probes specific for RARα and PML regions did not show a fusion signal as in APL. The breakpoints were assigned to 15q24.3 and 17q21.1. Detailed molecular analyses did not reveal any involvement of RARα and PML genes. The patient was resistant to several front-line AML treatments and to all-trans retinoic acid (ATRA). These findings reinforce FISH and RT-PCR as useful tools for the characterization of a t(15;17) as the translocation specifically associated with APL.

AB - We report a woman with acute myeloid leukaemia (AML) type M2 according to FAB classification, showing a t(15;17) apparently identical to that of acute promyelocytic leukaemia (APL) on conventional cytogenetic analysis. Fluorescence in situ hybridization (FISH) using cosmidic probes specific for RARα and PML regions did not show a fusion signal as in APL. The breakpoints were assigned to 15q24.3 and 17q21.1. Detailed molecular analyses did not reveal any involvement of RARα and PML genes. The patient was resistant to several front-line AML treatments and to all-trans retinoic acid (ATRA). These findings reinforce FISH and RT-PCR as useful tools for the characterization of a t(15;17) as the translocation specifically associated with APL.

KW - acute myeloid leukaemia

KW - acute promyelocytic leukaemia

KW - chromosomal abnormality

KW - fluorescence in situ hybridization

KW - t(15;17) translocation

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ER -

A (15;17) translocation not associated with acute promyelocytic leukaemia

Abstract

Keywords

ASJC Scopus subject areas

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