A [ 17F]-fluoromethane PET/TMS study of effective connectivity

Fabio Ferrarelli, H. Magnus Haraldsson, Todd E. Barnhart, Andy D. Roberts, Terrence R. Oakes, Marcello Massimini, Charles K. Stone, Ned H. Kalin, Giulio Tononi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [ 17F]- [CH 3F] ([ 17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [ 15O]-H 2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalBrain Research Bulletin
Volume64
Issue number2
DOIs
Publication statusPublished - Aug 30 2004

Fingerprint

Transcranial Magnetic Stimulation
Motor Cortex
Positron-Emission Tomography
Visual Cortex
Brain
fluoromethane

Keywords

  • Effective connectivity
  • Fluoromethane
  • Functional neuroimaging
  • Positron emission tomography
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ferrarelli, F., Haraldsson, H. M., Barnhart, T. E., Roberts, A. D., Oakes, T. R., Massimini, M., ... Tononi, G. (2004). A [ 17F]-fluoromethane PET/TMS study of effective connectivity. Brain Research Bulletin, 64(2), 103-113. https://doi.org/10.1016/j.brainresbull.2004.04.020

A [ 17F]-fluoromethane PET/TMS study of effective connectivity. / Ferrarelli, Fabio; Haraldsson, H. Magnus; Barnhart, Todd E.; Roberts, Andy D.; Oakes, Terrence R.; Massimini, Marcello; Stone, Charles K.; Kalin, Ned H.; Tononi, Giulio.

In: Brain Research Bulletin, Vol. 64, No. 2, 30.08.2004, p. 103-113.

Research output: Contribution to journalArticle

Ferrarelli, F, Haraldsson, HM, Barnhart, TE, Roberts, AD, Oakes, TR, Massimini, M, Stone, CK, Kalin, NH & Tononi, G 2004, 'A [ 17F]-fluoromethane PET/TMS study of effective connectivity', Brain Research Bulletin, vol. 64, no. 2, pp. 103-113. https://doi.org/10.1016/j.brainresbull.2004.04.020
Ferrarelli F, Haraldsson HM, Barnhart TE, Roberts AD, Oakes TR, Massimini M et al. A [ 17F]-fluoromethane PET/TMS study of effective connectivity. Brain Research Bulletin. 2004 Aug 30;64(2):103-113. https://doi.org/10.1016/j.brainresbull.2004.04.020
Ferrarelli, Fabio ; Haraldsson, H. Magnus ; Barnhart, Todd E. ; Roberts, Andy D. ; Oakes, Terrence R. ; Massimini, Marcello ; Stone, Charles K. ; Kalin, Ned H. ; Tononi, Giulio. / A [ 17F]-fluoromethane PET/TMS study of effective connectivity. In: Brain Research Bulletin. 2004 ; Vol. 64, No. 2. pp. 103-113.
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