A 1H magnetic resonance spectroscopy study in patients with obstructive sleep apnea

P. Sarchielli, O. Presciutti, A. Alberti, R. Tarducci, G. Gobbi, F. Galletti, C. Costa, P. Eusebi, P. Calabresi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background and purpose: Repeated episodes of hypoxia, hypercapnia and transient blood pressure elevation in obstructive sleep apnea syndrome (OSAS) may damage neutral structures and induce cerebral metabolic impairment. This study aimed to determine the impact of OSAS on cerebral metabolites measured by 1H magnetic resonance spectroscopy (1H -MRS). Methods: Twenty OSAS patients underwent standard overnight polysomnography and 1H-MRS separately. Proton volumes of interest (VOIs) were placed in frontal and midtemporal regions bilaterally. Results: Significantly lower values of the N-acetylaspartate (NAA)/creatine (Cr) ratio were found in frontal regions (P <0.004) compared with 20 age-matched control subjects. A significant increase in the myo-inositol (Ins)/Cr ratio was evident bilaterally in temporal and frontal regions (P <0.00002 and P <0.04). Choline (Cho)/Cr ratio values were also significantly greater in temporal regions (P <0.00001). A significant negative correlation (r = -0.51, P <0.03) was found between the apnea-hypopnea index (AHI) and NAA/Cr ratio in the frontal regions of OSAS patients. Conclusions: Reduction in the NAA/Cr ratio in frontal regions of OSAS patients could be related to neural loss. Increase in the Cho/Cr ratio in temporal regions and Ins/Cr ratio in both frontal and temporal regions could be interpreted as evidence of membrane breakdown and reactive gliosis, respectively, consequent to repeated episodes of hypoxia in OSAS.

Original languageEnglish
Pages (from-to)1058-1064
Number of pages7
JournalEuropean Journal of Neurology
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Creatine
Obstructive Sleep Apnea
Magnetic Resonance Spectroscopy
Temporal Lobe
Inositol
Choline
Gliosis
Hypercapnia
Polysomnography
Apnea
Protons
Blood Pressure
Membranes
N-acetylaspartate

Keywords

  • Metabolite ratios
  • Obstructive sleep apnea syndrome
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Medicine(all)

Cite this

A 1H magnetic resonance spectroscopy study in patients with obstructive sleep apnea. / Sarchielli, P.; Presciutti, O.; Alberti, A.; Tarducci, R.; Gobbi, G.; Galletti, F.; Costa, C.; Eusebi, P.; Calabresi, P.

In: European Journal of Neurology, Vol. 15, No. 10, 10.2008, p. 1058-1064.

Research output: Contribution to journalArticle

Sarchielli, P, Presciutti, O, Alberti, A, Tarducci, R, Gobbi, G, Galletti, F, Costa, C, Eusebi, P & Calabresi, P 2008, 'A 1H magnetic resonance spectroscopy study in patients with obstructive sleep apnea', European Journal of Neurology, vol. 15, no. 10, pp. 1058-1064. https://doi.org/10.1111/j.1468-1331.2008.02244.x
Sarchielli P, Presciutti O, Alberti A, Tarducci R, Gobbi G, Galletti F et al. A 1H magnetic resonance spectroscopy study in patients with obstructive sleep apnea. European Journal of Neurology. 2008 Oct;15(10):1058-1064. https://doi.org/10.1111/j.1468-1331.2008.02244.x
Sarchielli, P. ; Presciutti, O. ; Alberti, A. ; Tarducci, R. ; Gobbi, G. ; Galletti, F. ; Costa, C. ; Eusebi, P. ; Calabresi, P. / A 1H magnetic resonance spectroscopy study in patients with obstructive sleep apnea. In: European Journal of Neurology. 2008 ; Vol. 15, No. 10. pp. 1058-1064.
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abstract = "Background and purpose: Repeated episodes of hypoxia, hypercapnia and transient blood pressure elevation in obstructive sleep apnea syndrome (OSAS) may damage neutral structures and induce cerebral metabolic impairment. This study aimed to determine the impact of OSAS on cerebral metabolites measured by 1H magnetic resonance spectroscopy (1H -MRS). Methods: Twenty OSAS patients underwent standard overnight polysomnography and 1H-MRS separately. Proton volumes of interest (VOIs) were placed in frontal and midtemporal regions bilaterally. Results: Significantly lower values of the N-acetylaspartate (NAA)/creatine (Cr) ratio were found in frontal regions (P <0.004) compared with 20 age-matched control subjects. A significant increase in the myo-inositol (Ins)/Cr ratio was evident bilaterally in temporal and frontal regions (P <0.00002 and P <0.04). Choline (Cho)/Cr ratio values were also significantly greater in temporal regions (P <0.00001). A significant negative correlation (r = -0.51, P <0.03) was found between the apnea-hypopnea index (AHI) and NAA/Cr ratio in the frontal regions of OSAS patients. Conclusions: Reduction in the NAA/Cr ratio in frontal regions of OSAS patients could be related to neural loss. Increase in the Cho/Cr ratio in temporal regions and Ins/Cr ratio in both frontal and temporal regions could be interpreted as evidence of membrane breakdown and reactive gliosis, respectively, consequent to repeated episodes of hypoxia in OSAS.",
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