A 2019 update on TSH-secreting pituitary adenomas

P. Beck-Peccoz, C. Giavoli, A. Lania

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Thyrotropin-secreting pituitary adenomas (TSH-omas) present with signs and symptoms of hyperthyroidism and they are characterized by elevated serum levels of free thyroid hormones with measurable TSH levels. TSH-omas are very infrequent, accounting for less than 1% of all pituitary adenomas, thus representing a very rare cause of hyperthyroidism. For this reason, data collected on these rare disorders are relatively few, but some new researches shed new light on the etiopathogenesis, the diagnosis and the treatment of such a remarkable disease. Since the same biochemical picture is present in the syndromes of thyroid hormone resistance (RTH), in particular in the form of pituitary RTH, failure in distinguishing these clinical entities may lead to improper patient management. Conversely, early diagnosis and correct treatment of TSH-omas may prevent the occurrence of neurological and endocrinological complications, thus leading to a better rate of cure. In the present short review article, the most relevant recent advances in the pathophysiology of TSH-omas are described.

Original languageEnglish
JournalJournal of Endocrinological Investigation
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Pituitary Neoplasms
Hyperthyroidism
Thyroid Hormone Resistance Syndrome
Thyrotropin
Thyroid Hormones
Signs and Symptoms
Early Diagnosis
Therapeutics
Serum
Research

Keywords

  • Central hyperthyroidism
  • Free T3
  • Free T4
  • Resistance to thyroid hormones
  • Somatostatin analogs
  • Thyrotropin
  • Thyrotropin-secreting pituitary adenoma
  • Transsphenoidal surgery
  • TSH-oma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

A 2019 update on TSH-secreting pituitary adenomas. / Beck-Peccoz, P.; Giavoli, C.; Lania, A.

In: Journal of Endocrinological Investigation, 01.01.2019.

Research output: Contribution to journalReview article

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