A 3-day randomized clinical trial to investigate the desensitizing properties of three dentifrices

Giovanna Orsini, Maurizio Procaccini, Lamberto Manzoli, Scilla Sparabombe, Paolo Tiriduzzi, Fabrizio Bambini, Angelo Putignano

Research output: Contribution to journalArticle


Background: The aim of the present study is to evaluate the relative abilities of three desensitizing dentifrices to provide rapid relief of dentin hypersensitivity (DH). Methods: Using a double-mask, randomized design, three dentifrices: 1) containing 8% arginine and 1,450 ppm sodium monofluorophosphate; 2) containing 8% strontium acetate and 1,040 ppm sodium fluoride; and 3) containing 30% microaggregation of zinc-carbonate hydroxyapatite nanocrystals were compared after 3-day treatment. Participant́s DH was evaluated at baseline and after 3 days using air-blast, tactile, cold water, and subjective tests. Results: The final sample consisted of 85 individuals: 29 received the arginine-based dentifrice (group 1), 27 the strontium acetate-based dentifrice (group 2), and 29 the dentifrice based on zinc-carbonate hydroxyapatite (group 3). All dentifrices were mostly effective to reduce DH: the percentage of score reduction from baseline to 3 days was >30% for all tests (except for subjective test of group 2). The comparison among the three dentifrices showed that, after 3 days, there was an improvement in air-blast (mean percentage of reduction, 39.2% in group 1, 42.0% in group 2, and 39.2% in group 3), cold water (41.5%, 51.8%, and 50%), tactile (50.3%, 40.1%, and 33.8%), and subjective (33.1%, 17.4%, and 31.4%) test scores, with differences being significant for cold water and subjective tests. For air-blast and tactile tests, there were no significant differences across groups at 3 days. Moreover, no significant differences at any test were observed in a subset of patients that were followed up to 8 weeks: all dentifrices were all highly efficacious. Conclusions: This study documents that the three tested dentifrices significantly reduced DH after 3-day treatment, supporting their use in clinical practice. To the best of the authorś knowledge, this is the first report documenting the rapid relief from DH of a zinc-carbonate hydroxyapatite dentifrice. J Periodontol 2013;84:e65-e73.

Original languageEnglish
JournalJournal of Periodontology
Issue number11
Publication statusPublished - Nov 2013


  • Arginine
  • Clinical trial
  • Dentifrices
  • Dentin desensitizing agents
  • Research design
  • Strontium

ASJC Scopus subject areas

  • Periodontics

Fingerprint Dive into the research topics of 'A 3-day randomized clinical trial to investigate the desensitizing properties of three dentifrices'. Together they form a unique fingerprint.

  • Cite this

    Orsini, G., Procaccini, M., Manzoli, L., Sparabombe, S., Tiriduzzi, P., Bambini, F., & Putignano, A. (2013). A 3-day randomized clinical trial to investigate the desensitizing properties of three dentifrices. Journal of Periodontology, 84(11). https://doi.org/10.1902/jop.2013.120697