A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis

Massimiliano Calabrese, Maria A. Rocca, Matteo Atzori, Irene Mattisi, Alice Favaretto, Paola Perini, Paolo Gallo, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

Objective: We assessed the occurrence, extent, and frequency of formation of cortical lesions (CLs) in patients with relapsing-remitting (RR) and secondary progressive (SP) multiple sclerosis (MS), and their relationship with cortical atrophy and disability progression. Methods: One-hundred seven MS patients (76 RRMS and 31 SPMS), enrolled in a prospective, longitudinal magnetic resonance imaging (MRI) study, were assessed clinically and by brain MRI (including a double inversion recovery sequence) 3 years after study initiation. CL number and volume, T2 white matter (WM) lesion volume, gray matter fraction, and expanded disability status scale (EDSS) were measured. Results: At baseline, CLs were detected in 64.4% of RRMS and 74.2% of SPMS patients. During follow-up, 132 new CLs were found in 44 RRMS patients (57.9%; 0.8 new CL/patient/yr) and 61 in 15 SPMS patients (48.4%; 1.0 new CL/patient/yr). Among these patients, only 31 also showed at least 1 new WM lesion. CL number and volume increases were higher in the 52 patients with a clinical worsening compared with those without (p <0.001). Baseline CL volume correlated with baseline EDSS (r = 0.36, p <0.001) and EDSS changes over time (r = 0.51, p <0.001). Baseline CL volume was an independent predictor of EDSS accumulation and GM volume change at follow-up in both patient groups. In SPMS patients, baseline T2 WM lesion volume was another independent predictor of EDSS worsening.

Original languageEnglish
Pages (from-to)376-383
Number of pages8
JournalAnnals of Neurology
Volume67
Issue number3
DOIs
Publication statusPublished - Mar 2010

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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