A 3′UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection

Alessandra Pontillo, Lucas A. Brandão, Rafael L. Guimarães, Ludovica Segat, Emmanouil Athanasakis, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

Objectives: Innate immunity genes polymorphisms are known to be involved in the multifactorial susceptibility to HIV-1 infection. Recently it has been hypothesized that inflammasomes could play an important role in the host response to viruses. The aim of our study is to verify if single-nucleotide polymorphisms (SNPs) in genes encoding for NALPs-innate immune receptors that form molecular complexes leading to the production of IL-1beta and the activation of immune response-could influence the individual susceptibility to HIV-1. Design: We performed an association study analyzing 2 NLRP1 and NLRP3 SNPs in HIV-1 vertically infected Brazilian children (n = 135), HIV-1-infected Brazilain adults (n = 192) and HIV-1-positive Italian seropositive subjects (n = 192). Results: The 3UTR NLRP3 rs10754558 SNP was associated with HIV-1 infection in all the studied groups. The frequency of rs10754558 G allele was differently distributed within seropositive subjects (HIV+) and controls, and in particular the GG genotype was less frequent in HIV+. Conclusions: susceptibility to HIV-1 infection is associated with a 3UTR NLRP3 polymorphism. This is the first report linking SNPs in the NALPs with HIV-1 infection, and further epidemiologic and functional studies are needed to deeper investigate the role of inflammasome in the susceptibility to HIV-1 infection.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume54
Issue number3
DOIs
Publication statusPublished - Jul 1 2010

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Keywords

  • genetics
  • HIV-1
  • IL-1beta
  • inflammasome
  • innate immunity
  • NALP1/NLRP1
  • NALP3/NLRP3/CIAS1
  • polymorphisms

ASJC Scopus subject areas

  • Medicine(all)
  • Infectious Diseases
  • Pharmacology (medical)

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