TY - JOUR
T1 - A 5-year follow-up in deferasirox treatment
T2 - improvement of cardiac and hepatic iron overload and amelioration in cardiac function in thalassemia major patients
AU - Cassinerio, E.
AU - Roghi, A.
AU - Orofino, N.
AU - Pedrotti, P.
AU - Zanaboni, L.
AU - Poggiali, E.
AU - Giuditta, M.
AU - Consonni, D.
AU - Cappellini, M. D.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Deferasirox (DFX) is an oral iron chelator with established efficacy and safety. We evaluated by T2* cardiovascular magnetic resonance (CMR) the efficacy of DFX in preventing and removing cardiac and liver iron load and cardiac volume changes, along 5 years in adult thalassemia major (TM) patients. Twenty-three TM patients (9 males/14 women, mean age 36 ± 4 years) were included in this study. Repeated CMR was performed to assess myocardial and liver iron load (baseline t0, after 2.5 years t1, after 5 years t2). Myocardial T2* values changed progressively and increased significantly between t0 and t2 (t0: 27.15 ± 9.58 vs t2: 36.64 ± 6.68, p = 0.0001). At baseline evaluation, a cardiac T2* value
AB - Deferasirox (DFX) is an oral iron chelator with established efficacy and safety. We evaluated by T2* cardiovascular magnetic resonance (CMR) the efficacy of DFX in preventing and removing cardiac and liver iron load and cardiac volume changes, along 5 years in adult thalassemia major (TM) patients. Twenty-three TM patients (9 males/14 women, mean age 36 ± 4 years) were included in this study. Repeated CMR was performed to assess myocardial and liver iron load (baseline t0, after 2.5 years t1, after 5 years t2). Myocardial T2* values changed progressively and increased significantly between t0 and t2 (t0: 27.15 ± 9.58 vs t2: 36.64 ± 6.68, p = 0.0001). At baseline evaluation, a cardiac T2* value
KW - Cardiac iron overload
KW - Chelation therapy
KW - Deferasirox
KW - Liver iron overload
KW - Thalassemia major
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U2 - 10.1007/s00277-014-2291-x
DO - 10.1007/s00277-014-2291-x
M3 - Article
C2 - 25563596
AN - SCOPUS:84937511547
VL - 94
SP - 939
EP - 945
JO - Revue d'hématologie
JF - Revue d'hématologie
SN - 0939-5555
IS - 6
ER -