Abstract
Objective: To evaluate the 5-year variation of health-related quality of life (HRQoL) and mood symptoms in a cohort of patients with narcolepsy. Methods: Adults attending the Sleep Centre of the Department of Neurological Sciences, University of Bologna in 1997 and meeting the International Classification of Sleep Disorders-Revised criteria for the diagnosis of narcolepsy were eligible. Included patients self-administered the Medical Outcome Short Form-36 (SF-36) and the Zung depression scale (ZDS) prospectively in 1998 and 2003. Results: There was no significant difference between 1998 and 2003 measures of SF-36 and ZDS in the 54 patients included. About 25% of them showed moderate or severe mood symptoms in both observations. ZDS score (inversely) and duration of disease (directly) explained a percentage of variance of role physical, vitality (VT), social functioning (SF) and role emotional. At the second observation VT and SF had a further percentage of variance explained by excessive daytime sleepiness (EDS) and age at onset. Self-reported diabetes frequency doubled after 5 years (from 7% to 17%). Conclusions: Patients with narcolepsy show a stable impairment of HRQoL in a 5-year period with respect to Italian normative data. Mood status and EDS negatively influence their HRQoL while disease duration has a positive influence.
| Original language | English |
|---|---|
| Pages (from-to) | 19-23 |
| Number of pages | 5 |
| Journal | Sleep Medicine |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
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Keywords
- Cataplexy
- Depression
- Disorders of excessive somnolence
- Narcolepsy
- Prognosis
- Quality of life
- Questionnaires
ASJC Scopus subject areas
- Medicine(all)
Cite this
A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy. / Vignatelli, Luca; Plazzi, Giuseppe; Peschechera, Francesco; Delaj, Laureta; D'Alessandro, Roberto.
In: Sleep Medicine, Vol. 12, No. 1, 01.2011, p. 19-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy
AU - Vignatelli, Luca
AU - Plazzi, Giuseppe
AU - Peschechera, Francesco
AU - Delaj, Laureta
AU - D'Alessandro, Roberto
PY - 2011/1
Y1 - 2011/1
N2 - Objective: To evaluate the 5-year variation of health-related quality of life (HRQoL) and mood symptoms in a cohort of patients with narcolepsy. Methods: Adults attending the Sleep Centre of the Department of Neurological Sciences, University of Bologna in 1997 and meeting the International Classification of Sleep Disorders-Revised criteria for the diagnosis of narcolepsy were eligible. Included patients self-administered the Medical Outcome Short Form-36 (SF-36) and the Zung depression scale (ZDS) prospectively in 1998 and 2003. Results: There was no significant difference between 1998 and 2003 measures of SF-36 and ZDS in the 54 patients included. About 25% of them showed moderate or severe mood symptoms in both observations. ZDS score (inversely) and duration of disease (directly) explained a percentage of variance of role physical, vitality (VT), social functioning (SF) and role emotional. At the second observation VT and SF had a further percentage of variance explained by excessive daytime sleepiness (EDS) and age at onset. Self-reported diabetes frequency doubled after 5 years (from 7% to 17%). Conclusions: Patients with narcolepsy show a stable impairment of HRQoL in a 5-year period with respect to Italian normative data. Mood status and EDS negatively influence their HRQoL while disease duration has a positive influence.
AB - Objective: To evaluate the 5-year variation of health-related quality of life (HRQoL) and mood symptoms in a cohort of patients with narcolepsy. Methods: Adults attending the Sleep Centre of the Department of Neurological Sciences, University of Bologna in 1997 and meeting the International Classification of Sleep Disorders-Revised criteria for the diagnosis of narcolepsy were eligible. Included patients self-administered the Medical Outcome Short Form-36 (SF-36) and the Zung depression scale (ZDS) prospectively in 1998 and 2003. Results: There was no significant difference between 1998 and 2003 measures of SF-36 and ZDS in the 54 patients included. About 25% of them showed moderate or severe mood symptoms in both observations. ZDS score (inversely) and duration of disease (directly) explained a percentage of variance of role physical, vitality (VT), social functioning (SF) and role emotional. At the second observation VT and SF had a further percentage of variance explained by excessive daytime sleepiness (EDS) and age at onset. Self-reported diabetes frequency doubled after 5 years (from 7% to 17%). Conclusions: Patients with narcolepsy show a stable impairment of HRQoL in a 5-year period with respect to Italian normative data. Mood status and EDS negatively influence their HRQoL while disease duration has a positive influence.
KW - Cataplexy
KW - Depression
KW - Disorders of excessive somnolence
KW - Narcolepsy
KW - Prognosis
KW - Quality of life
KW - Questionnaires
UR - http://www.scopus.com/inward/record.url?scp=78650297753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650297753&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2010.07.008
DO - 10.1016/j.sleep.2010.07.008
M3 - Article
C2 - 20851047
AN - SCOPUS:78650297753
VL - 12
SP - 19
EP - 23
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 1
ER -