Abstract
The cell membrane appears to be one of the major targets of extremely low frequency (ELF) magnetic fields. To determine whether the membrane electrical properties of K562l leukaemic cells can be affected by ELF fields, these cells were exposed to a sinusoidal 50 Hz 2.5 mT magnetic field for 48 h. It should be recalled that the field intensity used is three or four orders of magnitude greater than the values found in homes and in many workplaces. Analyses of dielectric relaxation measurements in the r.f. range demonstrate that both the membrane electrical conductivity and permittivity of K562 cells decrease considerably after exposure of these cells to ELF fields, whereas the conductivity of the cytosol does not vary. Since both membrane conductivity (a measure of the dynamic ionic movement across cell membranes) and membrane permittivity (an indicator of the ionic charges present on cell membranes) vary, these data seem to suggest that exposure of K562 leukaemic cells to ELF fields affects both static and dynamic properties of these cells.
| Original language | English |
|---|---|
| Pages (from-to) | 39-45 |
| Number of pages | 7 |
| Journal | Bioelectrochemistry and Bioenergetics |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- 50 Hz magnetic field
- K562 erythroleukaemic cells
- Maxwell-Wagner effect
- Membrane electrical properties
ASJC Scopus subject areas
- Biochemistry
Cite this
A 50 Hz sinusoidal magnetic field induces changes in the membrane electrical properties of K562 leukaemic cells. / Santini, Maria Teresa; Cametti, Cesare; Paradisi, Silvia; Straface, Elisabetta; Donelli, Gianfranco; Indovina, Pietro Luigi; Malorni, Walter.
In: Bioelectrochemistry and Bioenergetics, Vol. 36, No. 1, 1995, p. 39-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A 50 Hz sinusoidal magnetic field induces changes in the membrane electrical properties of K562 leukaemic cells
AU - Santini, Maria Teresa
AU - Cametti, Cesare
AU - Paradisi, Silvia
AU - Straface, Elisabetta
AU - Donelli, Gianfranco
AU - Indovina, Pietro Luigi
AU - Malorni, Walter
PY - 1995
Y1 - 1995
N2 - The cell membrane appears to be one of the major targets of extremely low frequency (ELF) magnetic fields. To determine whether the membrane electrical properties of K562l leukaemic cells can be affected by ELF fields, these cells were exposed to a sinusoidal 50 Hz 2.5 mT magnetic field for 48 h. It should be recalled that the field intensity used is three or four orders of magnitude greater than the values found in homes and in many workplaces. Analyses of dielectric relaxation measurements in the r.f. range demonstrate that both the membrane electrical conductivity and permittivity of K562 cells decrease considerably after exposure of these cells to ELF fields, whereas the conductivity of the cytosol does not vary. Since both membrane conductivity (a measure of the dynamic ionic movement across cell membranes) and membrane permittivity (an indicator of the ionic charges present on cell membranes) vary, these data seem to suggest that exposure of K562 leukaemic cells to ELF fields affects both static and dynamic properties of these cells.
AB - The cell membrane appears to be one of the major targets of extremely low frequency (ELF) magnetic fields. To determine whether the membrane electrical properties of K562l leukaemic cells can be affected by ELF fields, these cells were exposed to a sinusoidal 50 Hz 2.5 mT magnetic field for 48 h. It should be recalled that the field intensity used is three or four orders of magnitude greater than the values found in homes and in many workplaces. Analyses of dielectric relaxation measurements in the r.f. range demonstrate that both the membrane electrical conductivity and permittivity of K562 cells decrease considerably after exposure of these cells to ELF fields, whereas the conductivity of the cytosol does not vary. Since both membrane conductivity (a measure of the dynamic ionic movement across cell membranes) and membrane permittivity (an indicator of the ionic charges present on cell membranes) vary, these data seem to suggest that exposure of K562 leukaemic cells to ELF fields affects both static and dynamic properties of these cells.
KW - 50 Hz magnetic field
KW - K562 erythroleukaemic cells
KW - Maxwell-Wagner effect
KW - Membrane electrical properties
UR - http://www.scopus.com/inward/record.url?scp=0029108764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029108764&partnerID=8YFLogxK
U2 - 10.1016/0302-4598(94)01750-U
DO - 10.1016/0302-4598(94)01750-U
M3 - Article
AN - SCOPUS:0029108764
VL - 36
SP - 39
EP - 45
JO - Bioelectrochemistry and Bioenergetics
JF - Bioelectrochemistry and Bioenergetics
SN - 0302-4598
IS - 1
ER -