A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

Mara Biasin; Manuela Sironi; Irma Saulle; Chiara Pontremoli; Micaela Garziano; Rachele Cagliani; Daria Trabattoni; Sergio Lo Caputo; Francesca Vichi; Francesco Mazzotta; Diego Forni; Stefania Riva; Wbeimar Aguilar-Jimenez; Samandhy Cedeño; Jorge Sanchez; Christian Brander; Wildeman Zapata; Maria Teresa Rugeles; Mario Clerici

doi:10.1016/j.micinf.2016.09.005

A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

Mara Biasin, Manuela Sironi, Irma Saulle, Chiara Pontremoli, Micaela Garziano, Rachele Cagliani, Daria Trabattoni, Sergio Lo Caputo, Francesca Vichi, Francesco Mazzotta, Diego Forni, Stefania Riva, Wbeimar Aguilar-Jimenez, Samandhy Cedeño, Jorge Sanchez, Christian Brander, Wildeman Zapata, Maria Teresa Rugeles, Mario Clerici

Research output: Contribution to journal › Article

Abstract

We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a . p value of 0.005. . In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

Original language	English
Pages (from-to)	69-74
Journal	Microbes and Infection
Volume	19(1)
Issue number	69-74
DOIs	https://doi.org/10.1016/j.micinf.2016.09.005
Publication status	Published - 2017

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Keywords

HESN
HIV
Polymorphism
Resistance to infection
TIM-1

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

Cite this

Biasin, M., Sironi, M., Saulle, I., Pontremoli, C., Garziano, M., Cagliani, R., Trabattoni, D., Lo Caputo, S., Vichi, F., Mazzotta, F., Forni, D., Riva, S., Aguilar-Jimenez, W., Cedeño, S., Sanchez, J., Brander, C., Zapata, W., Rugeles, M. T., & Clerici, M. (2017). A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. Microbes and Infection, 19(1)(69-74), 69-74. https://doi.org/10.1016/j.micinf.2016.09.005

A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. / Biasin, Mara; Sironi, Manuela; Saulle, Irma; Pontremoli, Chiara; Garziano, Micaela; Cagliani, Rachele; Trabattoni, Daria; Lo Caputo, Sergio; Vichi, Francesca; Mazzotta, Francesco; Forni, Diego; Riva, Stefania; Aguilar-Jimenez, Wbeimar; Cedeño, Samandhy; Sanchez, Jorge; Brander, Christian; Zapata, Wildeman; Rugeles, Maria Teresa; Clerici, Mario.

In: Microbes and Infection, Vol. 19(1), No. 69-74, 2017, p. 69-74.

Research output: Contribution to journal › Article

Biasin, M, Sironi, M, Saulle, I, Pontremoli, C, Garziano, M, Cagliani, R, Trabattoni, D, Lo Caputo, S, Vichi, F, Mazzotta, F, Forni, D, Riva, S, Aguilar-Jimenez, W, Cedeño, S, Sanchez, J, Brander, C, Zapata, W, Rugeles, MT & Clerici, M 2017, 'A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection', Microbes and Infection, vol. 19(1), no. 69-74, pp. 69-74. https://doi.org/10.1016/j.micinf.2016.09.005

Biasin, Mara ; Sironi, Manuela ; Saulle, Irma ; Pontremoli, Chiara ; Garziano, Micaela ; Cagliani, Rachele ; Trabattoni, Daria ; Lo Caputo, Sergio ; Vichi, Francesca ; Mazzotta, Francesco ; Forni, Diego ; Riva, Stefania ; Aguilar-Jimenez, Wbeimar ; Cedeño, Samandhy ; Sanchez, Jorge ; Brander, Christian ; Zapata, Wildeman ; Rugeles, Maria Teresa ; Clerici, Mario. / A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. In: Microbes and Infection. 2017 ; Vol. 19(1), No. 69-74. pp. 69-74.

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abstract = "We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a . p value of 0.005. . In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.",

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AU - Garziano, Micaela

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AU - Forni, Diego

AU - Riva, Stefania

AU - Aguilar-Jimenez, Wbeimar

AU - Cedeño, Samandhy

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AU - Brander, Christian

AU - Zapata, Wildeman

AU - Rugeles, Maria Teresa

AU - Clerici, Mario

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10.1016/j.micinf.2016.09.005