A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

Mara Biasin, Manuela Sironi, Irma Saulle, Chiara Pontremoli, Micaela Garziano, Rachele Cagliani, Daria Trabattoni, Sergio Lo Caputo, Francesca Vichi, Francesco Mazzotta, Diego Forni, Stefania Riva, Wbeimar Aguilar-Jimenez, Samandhy Cedeño, Jorge Sanchez, Christian Brander, Wildeman Zapata, Maria Teresa Rugeles, Mario Clerici

Research output: Contribution to journalArticle

Abstract

We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a . p value of 0.005. . In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

Original languageEnglish
Pages (from-to)69-74
JournalMicrobes and Infection
Volume19(1)
Issue number69-74
DOIs
Publication statusPublished - 2017

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Keywords

  • HESN
  • HIV
  • Polymorphism
  • Resistance to infection
  • TIM-1

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Biasin, M., Sironi, M., Saulle, I., Pontremoli, C., Garziano, M., Cagliani, R., Trabattoni, D., Lo Caputo, S., Vichi, F., Mazzotta, F., Forni, D., Riva, S., Aguilar-Jimenez, W., Cedeño, S., Sanchez, J., Brander, C., Zapata, W., Rugeles, M. T., & Clerici, M. (2017). A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. Microbes and Infection, 19(1)(69-74), 69-74. https://doi.org/10.1016/j.micinf.2016.09.005