A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

Mara Biasin, Manuela Sironi, Irma Saulle, Chiara Pontremoli, Micaela Garziano, Rachele Cagliani, Daria Trabattoni, Sergio Lo Caputo, Francesca Vichi, Francesco Mazzotta, Diego Forni, Stefania Riva, Wbeimar Aguilar-Jimenez, Samandhy Cedeño, Jorge Sanchez, Christian Brander, Wildeman Zapata, Maria Teresa Rugeles, Mario Clerici

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a . p value of 0.005. . In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

Original languageEnglish
Pages (from-to)69-74
JournalMicrobes and Infection
Volume19(1)
Issue number69-74
DOIs
Publication statusPublished - 2017

Fingerprint

Mucin-1
Mucins
HIV Infections
HIV-1
T-Lymphocytes
Amino Acids
Alleles
Peru
Colombia
Italy
Meta-Analysis
Immunoglobulin Domains
Infection
Population

Keywords

  • HESN
  • HIV
  • Polymorphism
  • Resistance to infection
  • TIM-1

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. / Biasin, Mara; Sironi, Manuela; Saulle, Irma; Pontremoli, Chiara; Garziano, Micaela; Cagliani, Rachele; Trabattoni, Daria; Lo Caputo, Sergio; Vichi, Francesca; Mazzotta, Francesco; Forni, Diego; Riva, Stefania; Aguilar-Jimenez, Wbeimar; Cedeño, Samandhy; Sanchez, Jorge; Brander, Christian; Zapata, Wildeman; Rugeles, Maria Teresa; Clerici, Mario.

In: Microbes and Infection, Vol. 19(1), No. 69-74, 2017, p. 69-74.

Research output: Contribution to journalArticle

Biasin, M, Sironi, M, Saulle, I, Pontremoli, C, Garziano, M, Cagliani, R, Trabattoni, D, Lo Caputo, S, Vichi, F, Mazzotta, F, Forni, D, Riva, S, Aguilar-Jimenez, W, Cedeño, S, Sanchez, J, Brander, C, Zapata, W, Rugeles, MT & Clerici, M 2017, 'A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection', Microbes and Infection, vol. 19(1), no. 69-74, pp. 69-74. https://doi.org/10.1016/j.micinf.2016.09.005
Biasin, Mara ; Sironi, Manuela ; Saulle, Irma ; Pontremoli, Chiara ; Garziano, Micaela ; Cagliani, Rachele ; Trabattoni, Daria ; Lo Caputo, Sergio ; Vichi, Francesca ; Mazzotta, Francesco ; Forni, Diego ; Riva, Stefania ; Aguilar-Jimenez, Wbeimar ; Cedeño, Samandhy ; Sanchez, Jorge ; Brander, Christian ; Zapata, Wildeman ; Rugeles, Maria Teresa ; Clerici, Mario. / A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. In: Microbes and Infection. 2017 ; Vol. 19(1), No. 69-74. pp. 69-74.
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