Abstract
We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a . p value of 0.005. . In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.
| Original language | English |
|---|---|
| Pages (from-to) | 69-74 |
| Journal | Microbes and Infection |
| Volume | 19(1) |
| Issue number | 69-74 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- HESN
- HIV
- Polymorphism
- Resistance to infection
- TIM-1
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases
Cite this
A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection. / Biasin, Mara; Sironi, Manuela; Saulle, Irma; Pontremoli, Chiara; Garziano, Micaela; Cagliani, Rachele; Trabattoni, Daria; Lo Caputo, Sergio; Vichi, Francesca; Mazzotta, Francesco; Forni, Diego; Riva, Stefania; Aguilar-Jimenez, Wbeimar; Cedeño, Samandhy; Sanchez, Jorge; Brander, Christian; Zapata, Wildeman; Rugeles, Maria Teresa; Clerici, Mario.
In: Microbes and Infection, Vol. 19(1), No. 69-74, 2017, p. 69-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection
AU - Biasin, Mara
AU - Sironi, Manuela
AU - Saulle, Irma
AU - Pontremoli, Chiara
AU - Garziano, Micaela
AU - Cagliani, Rachele
AU - Trabattoni, Daria
AU - Lo Caputo, Sergio
AU - Vichi, Francesca
AU - Mazzotta, Francesco
AU - Forni, Diego
AU - Riva, Stefania
AU - Aguilar-Jimenez, Wbeimar
AU - Cedeño, Samandhy
AU - Sanchez, Jorge
AU - Brander, Christian
AU - Zapata, Wildeman
AU - Rugeles, Maria Teresa
AU - Clerici, Mario
PY - 2017
Y1 - 2017
N2 - We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a . p value of 0.005. . In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.
AB - We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a . p value of 0.005. . In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.
KW - HESN
KW - HIV
KW - Polymorphism
KW - Resistance to infection
KW - TIM-1
UR - http://www.scopus.com/inward/record.url?scp=84994430954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994430954&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2016.09.005
DO - 10.1016/j.micinf.2016.09.005
M3 - Article
VL - 19(1)
SP - 69
EP - 74
JO - Microbes and Infection
JF - Microbes and Infection
SN - 1286-4579
IS - 69-74
ER -