A 6 month follow up study on response and relapse rates following an acute trial of repetitive transcranial magnetic stimulation (rTMS) in patients with major depression

Chiara Arici, Beatrice Benatti, Rita Cafaro, Laura Cremaschi, Luca Degoni, Sara Pozzoli, Lucio Oldani, Laura Molteni, Federica Giorgetti, Alberto Priori, Caterina Viganò, Bernardo Dell'Osso

Research output: Contribution to journalArticle

Abstract

Introduction: Little is known about post-acute effects of repetitive transcranial magnetic stimulation (rTMS) in patients with Major Depression. The present study focused on the 6 month-follow up of a sample of patients with Major Depression, after the completion of an acute 4 weeks rTMS trial, with the aim of evaluating response (in terms of sustained and late response) and relapse rates. Methods: Following the completion of an acute trial of rTMS (T0-T4), 31 drug-resistant depressed patients (bipolar or unipolar) entered a naturalistic follow-up period of six months, with three timepoints (T5, T6 and T7) during which they were assessed with the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Results: Results showed that in the 6 months following an acute TMS trial, a higher rate of late responders was observed among previously acute TMS non-responders (63,64%, 7 out of 11) compared to the rate of relapse among those who had acutely responded to TMS (10%, 2 out of 20). In addition, an overall high rate of maintained response (90%) was observed. Conclusion: Present findings seem to support the possibility of obtaining a clinical response also after the end of an acute TMS trial in patients with Major Depression. The concomitant low rate of relapse observed at the end of follow-up along with a high rate of maintained response provide further support to the post-acute efficacy of TMS. Nonetheless, further controlled studies with larger samples and longer follow-up observation are needed to confirm reported results.

Original languageEnglish
JournalCNS Spectrums
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Follow up
  • Late response
  • Major depression
  • Relapse
  • Repetitive tms (rtms)

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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