A 68-year-old Caucasian man presenting with urinary bladder lymphoepithelioma: A case report

Gian Paolo Spinelli, Giuseppe Lo Russo, Alberto Pacchiarotti, Valeria Stati, Alessandra Anna Prete, Federica Tomao, Cinzia Sciarretta, Mara Arduin, Enrico Basso, Stefania Chiotti, Marsela Sinjari, Martina Venezia, Giada Zoccoli, Silverio Tomao

Research output: Contribution to journalArticle

Abstract

Introduction. Lymphoepithelioma is a very rare form of malignant tumor originating from epithelial line cells. Its occurrence has potential clinical, therapeutic and prognostic implications. In the present report we describe an unusual case of bladder cancer with two different histological varieties: transition cell carcinoma and lymphoepithelioma-like carcinoma. Lymphoepithelioma-like carcinoma of the bladder has only been rarely reported in the literature to date. Case presentation. We present the case of a 68-year-old Caucasian man who, after occurrence of hematuria, underwent transurethral resection of a bladder tumor. The results of a histological examination confirmed a high-grade non-muscle-invasive pT1 lymphoepithelioma-like carcinoma of the urinary bladder, associated with a concurrent high-grade transition cell carcinoma. After analyzing the histological features, our patient was subjected to treatment with intra-vesical instillations of bacillus Calmette- Guérin. Our work stresses that diagnosis and therapeutic approaches can be difficult and controversial, especially in the early stages of this rare carcinoma. Conclusions: This report emphasizes the importance of extending our knowledge and experiences regarding this uncommon carcinoma. Further studies are needed to better understand this rare disease and define more accurate diagnostic and therapeutic strategies.

Original languageEnglish
Article number161
JournalJournal of Medical Case Reports
Volume7
DOIs
Publication statusPublished - 2013

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Urinary Bladder
Carcinoma
Urinary Bladder Neoplasms
Intravesical Administration
Hematuria
Therapeutics
Rare Diseases
Bacillus
Epithelial Cells
Neoplasms

Keywords

  • Bacillus Calmette-Guérin Instillations
  • Lymphoepithelioma-like Carcinoma
  • Urinary Bladder

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spinelli, G. P., Lo Russo, G., Pacchiarotti, A., Stati, V., Prete, A. A., Tomao, F., ... Tomao, S. (2013). A 68-year-old Caucasian man presenting with urinary bladder lymphoepithelioma: A case report. Journal of Medical Case Reports, 7, [161]. https://doi.org/10.1186/1752-1947-7-161

A 68-year-old Caucasian man presenting with urinary bladder lymphoepithelioma : A case report. / Spinelli, Gian Paolo; Lo Russo, Giuseppe; Pacchiarotti, Alberto; Stati, Valeria; Prete, Alessandra Anna; Tomao, Federica; Sciarretta, Cinzia; Arduin, Mara; Basso, Enrico; Chiotti, Stefania; Sinjari, Marsela; Venezia, Martina; Zoccoli, Giada; Tomao, Silverio.

In: Journal of Medical Case Reports, Vol. 7, 161, 2013.

Research output: Contribution to journalArticle

Spinelli, GP, Lo Russo, G, Pacchiarotti, A, Stati, V, Prete, AA, Tomao, F, Sciarretta, C, Arduin, M, Basso, E, Chiotti, S, Sinjari, M, Venezia, M, Zoccoli, G & Tomao, S 2013, 'A 68-year-old Caucasian man presenting with urinary bladder lymphoepithelioma: A case report', Journal of Medical Case Reports, vol. 7, 161. https://doi.org/10.1186/1752-1947-7-161
Spinelli, Gian Paolo ; Lo Russo, Giuseppe ; Pacchiarotti, Alberto ; Stati, Valeria ; Prete, Alessandra Anna ; Tomao, Federica ; Sciarretta, Cinzia ; Arduin, Mara ; Basso, Enrico ; Chiotti, Stefania ; Sinjari, Marsela ; Venezia, Martina ; Zoccoli, Giada ; Tomao, Silverio. / A 68-year-old Caucasian man presenting with urinary bladder lymphoepithelioma : A case report. In: Journal of Medical Case Reports. 2013 ; Vol. 7.
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AU - Prete, Alessandra Anna

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AB - Introduction. Lymphoepithelioma is a very rare form of malignant tumor originating from epithelial line cells. Its occurrence has potential clinical, therapeutic and prognostic implications. In the present report we describe an unusual case of bladder cancer with two different histological varieties: transition cell carcinoma and lymphoepithelioma-like carcinoma. Lymphoepithelioma-like carcinoma of the bladder has only been rarely reported in the literature to date. Case presentation. We present the case of a 68-year-old Caucasian man who, after occurrence of hematuria, underwent transurethral resection of a bladder tumor. The results of a histological examination confirmed a high-grade non-muscle-invasive pT1 lymphoepithelioma-like carcinoma of the urinary bladder, associated with a concurrent high-grade transition cell carcinoma. After analyzing the histological features, our patient was subjected to treatment with intra-vesical instillations of bacillus Calmette- Guérin. Our work stresses that diagnosis and therapeutic approaches can be difficult and controversial, especially in the early stages of this rare carcinoma. Conclusions: This report emphasizes the importance of extending our knowledge and experiences regarding this uncommon carcinoma. Further studies are needed to better understand this rare disease and define more accurate diagnostic and therapeutic strategies.

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