A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia

Gabriella Cirmena; Stefania Aliano; Giuseppina Fugazza; Roberto Bruzzone; Anna Garuti; Renata Bocciardi; Andrea Bacigalupo; Roberto Ravazzolo; Alberto Ballestrero; Mario Sessarego

doi:10.1016/j.cancergencyto.2008.02.005

A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia

Gabriella Cirmena, Stefania Aliano, Giuseppina Fugazza, Roberto Bruzzone, Anna Garuti, Renata Bocciardi, Andrea Bacigalupo, Roberto Ravazzolo, Alberto Ballestrero, Mario Sessarego

Research output: Contribution to journal › Article › peer-review

Abstract

We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	183
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2008.02.005
Publication status	Published - Jun 2008

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia. / Cirmena, Gabriella; Aliano, Stefania; Fugazza, Giuseppina; Bruzzone, Roberto; Garuti, Anna; Bocciardi, Renata; Bacigalupo, Andrea; Ravazzolo, Roberto; Ballestrero, Alberto; Sessarego, Mario.

In: Cancer Genetics and Cytogenetics, Vol. 183, No. 2, 06.2008, p. 105-108.

Research output: Contribution to journal › Article › peer-review

Cirmena, Gabriella ; Aliano, Stefania ; Fugazza, Giuseppina ; Bruzzone, Roberto ; Garuti, Anna ; Bocciardi, Renata ; Bacigalupo, Andrea ; Ravazzolo, Roberto ; Ballestrero, Alberto ; Sessarego, Mario. / A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia. In: Cancer Genetics and Cytogenetics. 2008 ; Vol. 183, No. 2. pp. 105-108.

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abstract = "We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.",

author = "Gabriella Cirmena and Stefania Aliano and Giuseppina Fugazza and Roberto Bruzzone and Anna Garuti and Renata Bocciardi and Andrea Bacigalupo and Roberto Ravazzolo and Alberto Ballestrero and Mario Sessarego",

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AU - Cirmena, Gabriella

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AU - Fugazza, Giuseppina

AU - Bruzzone, Roberto

AU - Garuti, Anna

AU - Bocciardi, Renata

AU - Bacigalupo, Andrea

AU - Ravazzolo, Roberto

AU - Ballestrero, Alberto

AU - Sessarego, Mario

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AB - We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.

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A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia

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