TY - JOUR
T1 - A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia
AU - Cirmena, Gabriella
AU - Aliano, Stefania
AU - Fugazza, Giuseppina
AU - Bruzzone, Roberto
AU - Garuti, Anna
AU - Bocciardi, Renata
AU - Bacigalupo, Andrea
AU - Ravazzolo, Roberto
AU - Ballestrero, Alberto
AU - Sessarego, Mario
PY - 2008/6
Y1 - 2008/6
N2 - We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.
AB - We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.
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U2 - 10.1016/j.cancergencyto.2008.02.005
DO - 10.1016/j.cancergencyto.2008.02.005
M3 - Article
C2 - 18503828
AN - SCOPUS:43949133894
VL - 183
SP - 105
EP - 108
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -