TY - JOUR
T1 - A biomarker of oxidative stress as a nontraditional risk factor in obese subjects
AU - Vassalle, Cristina
AU - Vigna, Luisella
AU - Bianchi, Sara
AU - Maffei, Silvia
AU - Novembrino, Cristina
AU - De Giuseppe, Rachele
AU - De Liso, Federica
AU - Vannucci, Alessandro
AU - Tirelli, Silvia
AU - Maiavacca, Rita
AU - Bamonti, Fabrizia
PY - 2013/8
Y1 - 2013/8
N2 - Background: Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. Materials & methods: Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m 2) and in 306 over- and normal-weight subjects (112 males, 194 females; age: 47 ± 12 years; BMI: 24 ± 3 kg/m2). Results: d-ROMs levels were higher in obese than in over- and normal-weight subjects (395 ± 104 vs 362 ± 102 and 351 ± 84 arbitrary units (AU); p <0.001), in women than males (390 ± 104 vs 327 ± 68 AU; p <0.001), in subjects with than those without hypertension (390 ± 103 vs 360 ± 95 AU; p <0.01) and in smokers than former and nonsmokers (380 ± 97 vs 358 ± 97 AU; p <0.05). A positive correlation was found between d-ROMs and BMI (r = 0.25; p <0.001) and age (r = 0.13; p <0.01). Levels of d-ROM (>75th percentile: 420 AU) remained as an independent obesity predictor (odds ratio: 2.5; p <0.001) in women. Continuous variables are reported as mean ± standard deviation. Conclusion: d-ROMs are a powerful obesity predictor, and could represent a reliable tool in obesity and cardiovascular risk evaluation, especially in women.
AB - Background: Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. Materials & methods: Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m 2) and in 306 over- and normal-weight subjects (112 males, 194 females; age: 47 ± 12 years; BMI: 24 ± 3 kg/m2). Results: d-ROMs levels were higher in obese than in over- and normal-weight subjects (395 ± 104 vs 362 ± 102 and 351 ± 84 arbitrary units (AU); p <0.001), in women than males (390 ± 104 vs 327 ± 68 AU; p <0.001), in subjects with than those without hypertension (390 ± 103 vs 360 ± 95 AU; p <0.01) and in smokers than former and nonsmokers (380 ± 97 vs 358 ± 97 AU; p <0.05). A positive correlation was found between d-ROMs and BMI (r = 0.25; p <0.001) and age (r = 0.13; p <0.01). Levels of d-ROM (>75th percentile: 420 AU) remained as an independent obesity predictor (odds ratio: 2.5; p <0.001) in women. Continuous variables are reported as mean ± standard deviation. Conclusion: d-ROMs are a powerful obesity predictor, and could represent a reliable tool in obesity and cardiovascular risk evaluation, especially in women.
KW - cardiovascular risk factors
KW - inflammation
KW - obesity
KW - oxidative stress
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U2 - 10.2217/bmm.13.49
DO - 10.2217/bmm.13.49
M3 - Article
C2 - 23905900
AN - SCOPUS:84881274941
VL - 7
SP - 633
EP - 639
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
SN - 1752-0363
IS - 4
ER -