A biomarker of oxidative stress as a nontraditional risk factor in obese subjects

Cristina Vassalle, Luisella Vigna, Sara Bianchi, Silvia Maffei, Cristina Novembrino, Rachele De Giuseppe, Federica De Liso, Alessandro Vannucci, Silvia Tirelli, Rita Maiavacca, Fabrizia Bamonti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. Materials & methods: Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m 2) and in 306 over- and normal-weight subjects (112 males, 194 females; age: 47 ± 12 years; BMI: 24 ± 3 kg/m2). Results: d-ROMs levels were higher in obese than in over- and normal-weight subjects (395 ± 104 vs 362 ± 102 and 351 ± 84 arbitrary units (AU); p <0.001), in women than males (390 ± 104 vs 327 ± 68 AU; p <0.001), in subjects with than those without hypertension (390 ± 103 vs 360 ± 95 AU; p <0.01) and in smokers than former and nonsmokers (380 ± 97 vs 358 ± 97 AU; p <0.05). A positive correlation was found between d-ROMs and BMI (r = 0.25; p <0.001) and age (r = 0.13; p <0.01). Levels of d-ROM (>75th percentile: 420 AU) remained as an independent obesity predictor (odds ratio: 2.5; p <0.001) in women. Continuous variables are reported as mean ± standard deviation. Conclusion: d-ROMs are a powerful obesity predictor, and could represent a reliable tool in obesity and cardiovascular risk evaluation, especially in women.

Original languageEnglish
Pages (from-to)633-639
Number of pages7
JournalBiomarkers in Medicine
Volume7
Issue number4
DOIs
Publication statusPublished - Aug 2013

Keywords

  • cardiovascular risk factors
  • inflammation
  • obesity
  • oxidative stress

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

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