A calorie-restricted diet decreases brain Iron accumulation and preserves motor performance in old rhesus monkeys

Erik K. Kastman, Auriel A. Willette, Christopher L. Coe, Barbara B. Bendlin, Kris J. Kosmatka, Donald G. McLaren, Guofan Xu, Elisa Canu, Aaron S. Field, Andrew L. Alexander, Mary Lou Voytko, T. Mark Beasley, Ricki J. Colman, Richard H. Weindruch, Sterling C. Johnson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Caloric restriction (CR) reduces the pathological effects of aging and extends the lifespan inmanyspecies, including nonhuman primates, although the effect on the brain is less well characterized. We used two common indicators of aging, motor performance speed and brain iron deposition measured in vivo using magnetic resonance imaging, to determine the potential effect of CR on elderly rhesus macaques eating restricted (n24, 13 males, 11 females) and standard (n17, 8 males, 9 females) diets. Both the CR and control monkeys showed age-related increases in iron concentrations in globus pallidus (GP) and substantia nigra (SN), although the CR group had significantly less iron deposition in the GP, SN, red nucleus, and temporal cortex.A Diet × Age interaction revealed thatCR modified age-related brain changes, evidenced as attenuation in the rate of iron accumulation in basal ganglia and parietal, temporal, and perirhinal cortex. Additionally, control monkeys had significantly slower fine motor performance on the Movement Assessment Panel, which was negatively correlated with iron accumulation in left SN and parietal lobe, although CR animals did not show this relationship. Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species.

Original languageEnglish
Pages (from-to)11897-11904
Number of pages8
JournalJournal of Neuroscience
Volume32
Issue number34
DOIs
Publication statusPublished - Aug 22 2012

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Caloric Restriction
Macaca mulatta
Iron
Diet
Brain
Substantia Nigra
Parietal Lobe
Globus Pallidus
Temporal Lobe
Primates
Haplorhini
Red Nucleus
Basal Ganglia
Rodentia
Eating
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., ... Johnson, S. C. (2012). A calorie-restricted diet decreases brain Iron accumulation and preserves motor performance in old rhesus monkeys. Journal of Neuroscience, 32(34), 11897-11904. https://doi.org/10.1523/JNEUROSCI.2553-12.2012

A calorie-restricted diet decreases brain Iron accumulation and preserves motor performance in old rhesus monkeys. / Kastman, Erik K.; Willette, Auriel A.; Coe, Christopher L.; Bendlin, Barbara B.; Kosmatka, Kris J.; McLaren, Donald G.; Xu, Guofan; Canu, Elisa; Field, Aaron S.; Alexander, Andrew L.; Voytko, Mary Lou; Mark Beasley, T.; Colman, Ricki J.; Weindruch, Richard H.; Johnson, Sterling C.

In: Journal of Neuroscience, Vol. 32, No. 34, 22.08.2012, p. 11897-11904.

Research output: Contribution to journalArticle

Kastman, EK, Willette, AA, Coe, CL, Bendlin, BB, Kosmatka, KJ, McLaren, DG, Xu, G, Canu, E, Field, AS, Alexander, AL, Voytko, ML, Mark Beasley, T, Colman, RJ, Weindruch, RH & Johnson, SC 2012, 'A calorie-restricted diet decreases brain Iron accumulation and preserves motor performance in old rhesus monkeys', Journal of Neuroscience, vol. 32, no. 34, pp. 11897-11904. https://doi.org/10.1523/JNEUROSCI.2553-12.2012
Kastman, Erik K. ; Willette, Auriel A. ; Coe, Christopher L. ; Bendlin, Barbara B. ; Kosmatka, Kris J. ; McLaren, Donald G. ; Xu, Guofan ; Canu, Elisa ; Field, Aaron S. ; Alexander, Andrew L. ; Voytko, Mary Lou ; Mark Beasley, T. ; Colman, Ricki J. ; Weindruch, Richard H. ; Johnson, Sterling C. / A calorie-restricted diet decreases brain Iron accumulation and preserves motor performance in old rhesus monkeys. In: Journal of Neuroscience. 2012 ; Vol. 32, No. 34. pp. 11897-11904.
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