A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA

Ana Márquez, Roser Solans, José Hernández-Rodríguez, Maria C. Cid, Santos Castañeda, Marc Ramentol, Luis Rodriguez-Rodriguez, Javier Narváez, Ricardo Blanco, Norberto Ortego-Centeno, Øyvind Palm, Andreas P. Diamantopoulos, Niko Braun, Frank Moosig, Torsten Witte, Lorenzo Beretta, Claudio Lunardi, Marco A. Cimmino, Augusto Vaglio, Carlo SalvaraniMiguel A. Gonzá Lez-Gay, Javier Martín

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on GCA predisposition.

Methods: A total of 1,363 biopsy-proven GCA patients and 3,908 healthy controls from four European cohorts (Spain, Italy, Germany and Norway) were combined in a meta-analysis. Six genetic variants: rs3939286, rs7025417 and rs7044343, within the IL33 gene, and rs2058660, rs2310173 and rs13015714, within the IL1RL1 gene, previously associated with immunerelated diseases, were genotyped using predesigned TaqMan assays.

Results: A consistent association between the rs7025417 polymorphism and GCA was evident in the overall meta-analysis, under both allele (PMH = 0.041, OR = 0.88, CI 95% 0.78-0.99) and recessive (PMH = 3.40E-03, OR = 0.53, CI 95% 0.35-0.80) models. No statistically significant differences between allele or genotype frequencies for the other IL33 and IL1RL1 genetic variants were detected in this pooled analysis.

Conclusions: Our results clearly evidenced the implication of the IL33 rs7025417 polymorphism in the genetic network underlying GCA.

Original languageEnglish
Article numbere113476
JournalPLoS One
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 19 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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