A case-control and family-based association study of the 5-HTTLPR in pediatric-onset depressive disorders

Maria Nobile, Maria Giulia Cataldo, Roberto Giorda, Marco Battaglia, Cinzia Baschirotto, Monica Bellina, Cecilia Marino, Massimo Molteni

Research output: Contribution to journalArticle


Pediatric depression can be particularly informative for clarification of the causes of mood disorders. The aim of this work was to explore the possible association between childhood- and early-adolescent-onset DSM-IV depressive disorders (DD; including major depression and dysthymia) and the serotonin transporter-linked promoter polymorphism (5-HTTLPR) locus. The case-control sample consisted of 68 unrelated patients with DD, and 68 unrelated age- and gender-matched healthy control subjects. The same patients were included in the family-based study, which consisted of 41 triads and 11 dyads. An excess of the SS-genotype (p = .025) and of the S-allele (p = .021) was found among DD children (odds ratio = 1.81; 95% confidence interval = 1.122.94). The family-based results suggested that the S-allele was preferentially transmitted to depressed children (haplotype-based haplotype relative risk: χ 2 = 7.231 df = 1, p = .007; transmission disequilibrium test: χ 2 = 5.233, df = 1, p = .022). A role for the 5-HTTLPR locus that needs replication in larger samples is suggested in childhood DD.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalBiological Psychiatry
Issue number4
Publication statusPublished - Aug 15 2004



  • Adolescent
  • association
  • child
  • depression
  • serotonin transporter promoter

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this