TY - JOUR
T1 - A case-control and family-based association study of the 5-HTTLPR in pediatric-onset depressive disorders
AU - Nobile, Maria
AU - Cataldo, Maria Giulia
AU - Giorda, Roberto
AU - Battaglia, Marco
AU - Baschirotto, Cinzia
AU - Bellina, Monica
AU - Marino, Cecilia
AU - Molteni, Massimo
PY - 2004/8/15
Y1 - 2004/8/15
N2 - Pediatric depression can be particularly informative for clarification of the causes of mood disorders. The aim of this work was to explore the possible association between childhood- and early-adolescent-onset DSM-IV depressive disorders (DD; including major depression and dysthymia) and the serotonin transporter-linked promoter polymorphism (5-HTTLPR) locus. The case-control sample consisted of 68 unrelated patients with DD, and 68 unrelated age- and gender-matched healthy control subjects. The same patients were included in the family-based study, which consisted of 41 triads and 11 dyads. An excess of the SS-genotype (p = .025) and of the S-allele (p = .021) was found among DD children (odds ratio = 1.81; 95% confidence interval = 1.122.94). The family-based results suggested that the S-allele was preferentially transmitted to depressed children (haplotype-based haplotype relative risk: χ
2 = 7.231 df = 1, p = .007; transmission disequilibrium test: χ
2 = 5.233, df = 1, p = .022). A role for the 5-HTTLPR locus that needs replication in larger samples is suggested in childhood DD.
AB - Pediatric depression can be particularly informative for clarification of the causes of mood disorders. The aim of this work was to explore the possible association between childhood- and early-adolescent-onset DSM-IV depressive disorders (DD; including major depression and dysthymia) and the serotonin transporter-linked promoter polymorphism (5-HTTLPR) locus. The case-control sample consisted of 68 unrelated patients with DD, and 68 unrelated age- and gender-matched healthy control subjects. The same patients were included in the family-based study, which consisted of 41 triads and 11 dyads. An excess of the SS-genotype (p = .025) and of the S-allele (p = .021) was found among DD children (odds ratio = 1.81; 95% confidence interval = 1.122.94). The family-based results suggested that the S-allele was preferentially transmitted to depressed children (haplotype-based haplotype relative risk: χ
2 = 7.231 df = 1, p = .007; transmission disequilibrium test: χ
2 = 5.233, df = 1, p = .022). A role for the 5-HTTLPR locus that needs replication in larger samples is suggested in childhood DD.
KW - Adolescent
KW - association
KW - child
KW - depression
KW - serotonin transporter promoter
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UR - http://www.scopus.com/inward/citedby.url?scp=4143123257&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2004.05.018
DO - 10.1016/j.biopsych.2004.05.018
M3 - Article
C2 - 15312818
AN - SCOPUS:4143123257
VL - 56
SP - 292
EP - 295
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 4
ER -