A case-control and family-based association study of the 5-HTTLPR in pediatric-onset depressive disorders

Maria Nobile, Maria Giulia Cataldo, Roberto Giorda, Marco Battaglia, Cinzia Baschirotto, Monica Bellina, Cecilia Marino, Massimo Molteni

Research output: Contribution to journalArticle

Abstract

Pediatric depression can be particularly informative for clarification of the causes of mood disorders. The aim of this work was to explore the possible association between childhood- and early-adolescent-onset DSM-IV depressive disorders (DD; including major depression and dysthymia) and the serotonin transporter-linked promoter polymorphism (5-HTTLPR) locus. The case-control sample consisted of 68 unrelated patients with DD, and 68 unrelated age- and gender-matched healthy control subjects. The same patients were included in the family-based study, which consisted of 41 triads and 11 dyads. An excess of the SS-genotype (p = .025) and of the S-allele (p = .021) was found among DD children (odds ratio = 1.81; 95% confidence interval = 1.122.94). The family-based results suggested that the S-allele was preferentially transmitted to depressed children (haplotype-based haplotype relative risk: χ 2 = 7.231 df = 1, p = .007; transmission disequilibrium test: χ 2 = 5.233, df = 1, p = .022). A role for the 5-HTTLPR locus that needs replication in larger samples is suggested in childhood DD.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalBiological Psychiatry
Volume56
Issue number4
DOIs
Publication statusPublished - Aug 15 2004

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Keywords

  • Adolescent
  • association
  • child
  • depression
  • serotonin transporter promoter

ASJC Scopus subject areas

  • Biological Psychiatry

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