A case-control study for multidrug-resistant tuberculosis

Risk factors in four European countries

Manuel Casal, M. Vaquero, H. Rinder, E. Tortoli, J. Grosset, S. Rüsch-Gerdes, J. Gutiérrez, V. Jarlier

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to detect risk factors for multidrug resistance in patients with pulmonary tuberculosis in four European Union countries: France, Germany, Italy, and Spain. A prospective epidemiological case control study was conducted, made up of patients with clinically diagnosed and microbiologically confirmed pulmonary tuberculosis in the four countries between 1997 and 2000. A total of 138 cases and 276 contols were studied. Considering the four countries as a whole, the most statistically significant risk factors were as follows: intravenous drug use (OR 4.68); asylum-seeker support (OR 2.55) as income factor; living in a nursing home (OR 2.05); previous tuberculosis (OR 2.03) with pulmonary location; prison (OR 2.02); known tuberculosis contacts (OR 2.01); immunosuppression other than human immunodeficiency virus (HIV) (OR 1.96); acquired immunodeficiency syndrome (AIDS) (OR 1.96); current tuberculosis with pulmonary location (OR 1.77); and health-care worker (OR 1.69). These risk factors will have to be taken into account in the European Union as a whole, as well as in each individual country, to establish a health policy of monitoring and control for these cases of multidrug resistance. Although rare, their seriousness makes them particularly important.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalMicrobial Drug Resistance
Volume11
Issue number1
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Multidrug-Resistant Tuberculosis
Pulmonary Tuberculosis
Case-Control Studies
Multiple Drug Resistance
European Union
Tuberculosis
Refugees
Prisons
Health Policy
Nursing Homes
Spain
Immunosuppression
Italy
France
Germany
Acquired Immunodeficiency Syndrome
HIV
Delivery of Health Care
Lung
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology
  • Immunology
  • Microbiology

Cite this

Casal, M., Vaquero, M., Rinder, H., Tortoli, E., Grosset, J., Rüsch-Gerdes, S., ... Jarlier, V. (2005). A case-control study for multidrug-resistant tuberculosis: Risk factors in four European countries. Microbial Drug Resistance, 11(1), 62-67. https://doi.org/10.1089/mdr.2005.11.62

A case-control study for multidrug-resistant tuberculosis : Risk factors in four European countries. / Casal, Manuel; Vaquero, M.; Rinder, H.; Tortoli, E.; Grosset, J.; Rüsch-Gerdes, S.; Gutiérrez, J.; Jarlier, V.

In: Microbial Drug Resistance, Vol. 11, No. 1, 03.2005, p. 62-67.

Research output: Contribution to journalArticle

Casal, M, Vaquero, M, Rinder, H, Tortoli, E, Grosset, J, Rüsch-Gerdes, S, Gutiérrez, J & Jarlier, V 2005, 'A case-control study for multidrug-resistant tuberculosis: Risk factors in four European countries', Microbial Drug Resistance, vol. 11, no. 1, pp. 62-67. https://doi.org/10.1089/mdr.2005.11.62
Casal, Manuel ; Vaquero, M. ; Rinder, H. ; Tortoli, E. ; Grosset, J. ; Rüsch-Gerdes, S. ; Gutiérrez, J. ; Jarlier, V. / A case-control study for multidrug-resistant tuberculosis : Risk factors in four European countries. In: Microbial Drug Resistance. 2005 ; Vol. 11, No. 1. pp. 62-67.
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