A case-control study of betapapillomavirus infection and cutaneous squamous cell carcinoma in organ transplant recipients

C. M. Proby, C. A. Harwood, R. E. Neale, A. C. Green, S. Euvrard, L. Naldi, G. Tessari, M. C W Feltkamp, M. N C De Koning, W. G V Quint, T. Waterboer, M. Pawlita, S. Weissenborn, U. Wieland, H. Pfister, E. Stockfleth, I. Nindl, D. Abeni, J. Ter Schegget, J. N. Bouwes Bavinck

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the association between betapapillomavirus (betaPV) infection and cutaneous squamous cell carcinoma (SCC) in organ transplant recipients. A total of 210 organ transplant recipients with previous SCC and 394 controls without skin cancer were included. The presence of 25 betaPV types in plucked eyebrow hairs was determined using a human papillomavirus (HPV) DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types were detected using multiplex serology. We used multivariate logistic regression models to estimate associations between various measures of betaPV infection and SCC. BetaPV DNA was highly prevalent (>94%) with multiple types frequently detected in both groups. We found a significant association between SCC and the concordant detection of both antibodies and DNA for at least one betaPV type (adjusted OR 1.6; 95% CI 1.1;2.5). A borderline-significant association with SCC was found for HPV36 (adjusted OR 2.4; CI 1.0;5.4), with similar associations for HPV5, HPV9 and HPV24. These data provide further evidence of an association between betaPV infection and SCC in organ transplant recipients. Confirmation of a betaPV profile predictive of risk for SCC may pave the way for clinically relevant pretransplant HPV screening and the development of preventive and therapeutic HPV vaccination.

Original languageEnglish
Pages (from-to)1498-1508
Number of pages11
JournalAmerican Journal of Transplantation
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Betapapillomavirus
  • case-control study
  • cutaneous squamous cell carcinoma
  • organ transplant recipient

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'A case-control study of betapapillomavirus infection and cutaneous squamous cell carcinoma in organ transplant recipients'. Together they form a unique fingerprint.

Cite this