A case-control study of gastric cancer and diet in Italy: II. Association with nutrients

E. Buiatti, D. Palli, A. Decarli, D. Amadori, C. Avellini, S. Bianchi, C. Bonaguri, F. Cipriani, P. Cocco, A. Giacosa, E. Marubini, C. Minacci, R. Puntoni, A. Russo, C. Vindigni, J. F. Fraumeni, W. J. BLot

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

A case-control study involving interviews with 1,016 gastric cancer (GC) patients and 1,159 population-based controls in high- and low-risk areas was conducted to evaluate dietary factors and their contribution to the marked geographic variation in mortality from this cancer within Italy. Risks of GC were found to vary significantly with estimated nutrient intake. Risk rose with increasing consumption of nitrites and protein, and decreased in proportion to intake of ascorbic acid, beta-carotene, alpha-tocopherol, and vegetable fat. The associations with nitrite and beta-carotene tended to fade, however, in multivariate analyses adjusting for intake of other nutrients. Ascorbic acid showed the strongest geographic gradient, which highest consumption in low-risk areas. The findings suggest that the protective effects we previously reported for consumption of fresh fruit, fresh vegetables and olive oil may be linked to the vitamins C and E contained in these foods. The findings are consistent with the hypothesis that N-nitroso compounds are involved in GC risks, since elevated risks were apparent for agents (nitrites, protein) that promote nitrosation, while decreased risks were found for nutrients (ascorbic acid and alpha-tocopherol) which inhibit the process.

Original languageEnglish
Pages (from-to)896-901
Number of pages6
JournalInternational Journal of Cancer
Volume45
Issue number5
DOIs
Publication statusPublished - 1990

Fingerprint

Italy
Stomach Neoplasms
Case-Control Studies
Diet
Food
Ascorbic Acid
Nitrites
beta Carotene
alpha-Tocopherol
Nitrosation
Nitroso Compounds
Plant Oils
Population Control
Vitamin E
Vegetables
Fruit
Proteins
Multivariate Analysis
Fats
Interviews

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Buiatti, E., Palli, D., Decarli, A., Amadori, D., Avellini, C., Bianchi, S., ... BLot, W. J. (1990). A case-control study of gastric cancer and diet in Italy: II. Association with nutrients. International Journal of Cancer, 45(5), 896-901. https://doi.org/10.1002/ijc.2910450520

A case-control study of gastric cancer and diet in Italy : II. Association with nutrients. / Buiatti, E.; Palli, D.; Decarli, A.; Amadori, D.; Avellini, C.; Bianchi, S.; Bonaguri, C.; Cipriani, F.; Cocco, P.; Giacosa, A.; Marubini, E.; Minacci, C.; Puntoni, R.; Russo, A.; Vindigni, C.; Fraumeni, J. F.; BLot, W. J.

In: International Journal of Cancer, Vol. 45, No. 5, 1990, p. 896-901.

Research output: Contribution to journalArticle

Buiatti, E, Palli, D, Decarli, A, Amadori, D, Avellini, C, Bianchi, S, Bonaguri, C, Cipriani, F, Cocco, P, Giacosa, A, Marubini, E, Minacci, C, Puntoni, R, Russo, A, Vindigni, C, Fraumeni, JF & BLot, WJ 1990, 'A case-control study of gastric cancer and diet in Italy: II. Association with nutrients', International Journal of Cancer, vol. 45, no. 5, pp. 896-901. https://doi.org/10.1002/ijc.2910450520
Buiatti, E. ; Palli, D. ; Decarli, A. ; Amadori, D. ; Avellini, C. ; Bianchi, S. ; Bonaguri, C. ; Cipriani, F. ; Cocco, P. ; Giacosa, A. ; Marubini, E. ; Minacci, C. ; Puntoni, R. ; Russo, A. ; Vindigni, C. ; Fraumeni, J. F. ; BLot, W. J. / A case-control study of gastric cancer and diet in Italy : II. Association with nutrients. In: International Journal of Cancer. 1990 ; Vol. 45, No. 5. pp. 896-901.
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AU - Decarli, A.

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AU - Avellini, C.

AU - Bianchi, S.

AU - Bonaguri, C.

AU - Cipriani, F.

AU - Cocco, P.

AU - Giacosa, A.

AU - Marubini, E.

AU - Minacci, C.

AU - Puntoni, R.

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AU - Vindigni, C.

AU - Fraumeni, J. F.

AU - BLot, W. J.

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