A case-control study on excessive daytime sleepiness in episodic migraine

P. Barbanti, G. Fabbrini, C. Aurilia, N. Vanacore, G. Cruccu

Research output: Contribution to journalArticlepeer-review


Migraine patients often complain of sleepiness, a problem that manifests both during and outside an attack, may impair the quality of life and can lead to potentially harmful situations. Findings from an uncontrolled study suggest that a high percentage of migraineurs experience excessive daytime sleepiness (EDS). We investigated EDS in a case-control study on 100 patients with episodic migraine and 100 age- and sex-matched healthy controls and also assessed sleep quality, anxiety and depression. Although it was found that EDS was more frequent in migraineurs than in controls (14% vs. 5%; odds ratio 3.1; 95% confidence interval 1.1-8.9), the frequency was lower than previously reported. EDS correlated with migraine disability, sleep problems and anxiety. EDS in patients with migraine probably stems from the full constellation of headache-sleep-affective symptoms resulting from the complex clinical burden of the disease.

Original languageEnglish
Pages (from-to)1115-1119
Number of pages5
Issue number10
Publication statusPublished - Oct 2007


  • Anxiety
  • Depression
  • Disability
  • Excessive daytime sleepiness
  • Migraine
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology


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