TY - JOUR
T1 - A case of acute lymphoblastic leukemia presenting as severe hypercalcemia
AU - Buonuomo, Paola Sabrina
AU - Ruggiero, Antonio
AU - Piastra, Marco
AU - Riccardi, Riccardo
AU - Polidori, Giancarlo
AU - Chiaretti, Antonio
PY - 2004/9
Y1 - 2004/9
N2 - A 9-year-old girl presented at the Pediatric Emergency Department with an acute onset of gastrointestinal symptoms due to hypercalcemia. Despite the absence of circulating blast, bone marrow biopsy was diagnostic of acute lymphoblastic leukemia. The hypercalcemia was initially treated with intravenous hydration and furosemide, and later on with bisphosphonates. However, the serum calcium levels normalized only after the beginning of specific chemotherapy. Hypercalcemia represents an emergency in children, and acute leukemia must be considered in its differential diagnosis, even when there are no circulating blasts.
AB - A 9-year-old girl presented at the Pediatric Emergency Department with an acute onset of gastrointestinal symptoms due to hypercalcemia. Despite the absence of circulating blast, bone marrow biopsy was diagnostic of acute lymphoblastic leukemia. The hypercalcemia was initially treated with intravenous hydration and furosemide, and later on with bisphosphonates. However, the serum calcium levels normalized only after the beginning of specific chemotherapy. Hypercalcemia represents an emergency in children, and acute leukemia must be considered in its differential diagnosis, even when there are no circulating blasts.
KW - Bisphosphonates
KW - Childhood
KW - Hypercalcemia
KW - Leukemia
UR - http://www.scopus.com/inward/record.url?scp=4444279164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444279164&partnerID=8YFLogxK
U2 - 10.1080/08880010490477248
DO - 10.1080/08880010490477248
M3 - Article
C2 - 15552810
AN - SCOPUS:4444279164
VL - 21
SP - 475
EP - 479
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 6
ER -