A case of acute lymphoblastic leukemia presenting as severe hypercalcemia

Paola Sabrina Buonuomo, Antonio Ruggiero, Marco Piastra, Riccardo Riccardi, Giancarlo Polidori, Antonio Chiaretti

Research output: Contribution to journalArticlepeer-review


A 9-year-old girl presented at the Pediatric Emergency Department with an acute onset of gastrointestinal symptoms due to hypercalcemia. Despite the absence of circulating blast, bone marrow biopsy was diagnostic of acute lymphoblastic leukemia. The hypercalcemia was initially treated with intravenous hydration and furosemide, and later on with bisphosphonates. However, the serum calcium levels normalized only after the beginning of specific chemotherapy. Hypercalcemia represents an emergency in children, and acute leukemia must be considered in its differential diagnosis, even when there are no circulating blasts.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalPediatric Hematology and Oncology
Issue number6
Publication statusPublished - Sep 2004


  • Bisphosphonates
  • Childhood
  • Hypercalcemia
  • Leukemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research


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