Abstract
Neutrophil nuclear hyposegmentation, known as the Pelger-Huet anomaly, is frequent in myeloproliferative diseases. We report a case of a woman with acute myeloid leukemia (M2) presenting pseudo-Pelger type neutrophils in apparently complete bone marrow remission. We studied neutrophil function and C.F.U.-G.M. colonies obtained from in-vitro culture of bone marrow and circulating cells. Neutrophil function tests showed an increase in the LAP score and a deficit in chemotaxis. The data obtained from in-vitro culture of granulocyte pregenitor cells (C.F.U. -G.M.) demonstrated an increased number of clusters. The Pelger-Huet anomaly is always a sign of altered bone marrow regulatory mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 709-715 |
| Number of pages | 7 |
| Journal | Medecine Biologie Environment |
| Volume | 13 |
| Issue number | 1 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Ricevuti, G., Mazzone, A., & Carlo Stella, C. (1985). A case of acute myeloid leukemia, with pseudo-Pelger neutrophils. Medecine Biologie Environment, 13(1), 709-715.