A case of acute myeloid leukemia, with pseudo-Pelger neutrophils

G. Ricevuti, A. Mazzone, C. Carlo Stella

Research output: Contribution to journalArticle

Abstract

Neutrophil nuclear hyposegmentation, known as the Pelger-Huet anomaly, is frequent in myeloproliferative diseases. We report a case of a woman with acute myeloid leukemia (M2) presenting pseudo-Pelger type neutrophils in apparently complete bone marrow remission. We studied neutrophil function and C.F.U.-G.M. colonies obtained from in-vitro culture of bone marrow and circulating cells. Neutrophil function tests showed an increase in the LAP score and a deficit in chemotaxis. The data obtained from in-vitro culture of granulocyte pregenitor cells (C.F.U. -G.M.) demonstrated an increased number of clusters. The Pelger-Huet anomaly is always a sign of altered bone marrow regulatory mechanisms.

Original languageEnglish
Pages (from-to)709-715
Number of pages7
JournalMedecine Biologie Environment
Volume13
Issue number1
Publication statusPublished - 1985

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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