A case of asymptomatic pontine myelinolysis

Angelica Lupato, Patrik Fazio, Enrico Fainardi, Edoardo Cesnik, Ilaria Casetta, Enrico Granieri

Research output: Contribution to journalArticlepeer-review


Central pontine myelinolysis is an acquired, non-inflammatory demyelinating lesion usually localized in the brainstem pons basis; it usually affects patients with a history of chronic alcoholism, malnutrition or dysionemia. The exact pathogenesis of myelinolysis is still unclear. A 69-year-old Caucasian male presented intensive headache and underwent cranial MRI that showed the typical feature of central pontine myelinolysis. Neurological valuation was negative. Other examinations included extensive blood tests, electroencephalogram and multimodal evoked potentials which all gave normal results. Alcohol abuse and malabsorption syndrome were excluded. The medical history revealed a continuative use of anti-depressive drugs and exposure to glue for years. Our patient may represent one of the rare cases of asymptomatic CPM. The actual reason why he presented this lesion is not clear, but we discuss the possible role in the etiopathogenesis of his chronic use of anti-depressive drugs and the exposure to glue and chemical agents.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalNeurological Sciences
Issue number3
Publication statusPublished - Jun 2010


  • Apparent diffusion coefficient
  • Asymptomatic myelinolysis
  • Central pontine myelinolysis
  • Hyponatraemia

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)


Dive into the research topics of 'A case of asymptomatic pontine myelinolysis'. Together they form a unique fingerprint.

Cite this