Una diagnosi in laboratorio

Translated title of the contribution: A case of atypical celiac disease with hematological involvement

Federica De Liso, Mariangela Ronchi, Caterina Matinato, Norma Nadia Fantini, Rita Maiavacca

Research output: Contribution to journalArticlepeer-review


We report a case of a pregnant 39 year-old woman (22th week) with leuco-granulocitopenia, iron-deficiency anemia and a slight elevation of transaminases, lasting for several years. The origin of these biochemical alterations was unclear. Assuming a possible autoimmune condition, she underwent a hematological counselling in order to verify the presence of an immunological disorder. Anti-nuclear antibodies resulted negative with a citoplasmic filamentous fluorescence suggestive of anti-smooth muscle antibodies (ASMA). On a suitable substrate for ASMA detection, a reticulin-like fluorescence was observed, inducing to investigate for the presence of celiac disease (CD). CD diagnosis requires both the biochemical tests and duodenal biopsy; however, because of the pregnancy only the serum panel was performed (serum IgA, anti-tissue transglutaminase IgA, anti- endomisium IgA). As the tests were all positive, clinicians decided to start the gluten free diet with an improvement of the hematological and biochemical parameters. The patient gave birth to a healthy newborn.

Translated title of the contributionA case of atypical celiac disease with hematological involvement
Original languageItalian
Pages (from-to)e8-e11
JournalBiochimica Clinica
Issue number1
Publication statusPublished - Jan 1 2018

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical


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