A case of bilateral breast cancer and Grave's disease

Mario Benedetti, Francesco Paolo Tinozzi, Simone Albertario, Carlo Bianchi, Thekla Niebel, Alberto Vailati, Marco Danova, Stefano Tinozzi

Research output: Contribution to journalArticlepeer-review


We report a case of bilateral breast cancer associated with Graves' disease characterized by a large goiter and complicated by a severe ophthalmopathy. The hyperthyroidism was treated initially with methimazole and then with thyroidectomy, the ophthalmopathy with intravenous steroids combined with orbital radiotherapy. The breast tumors underwent surgical resection followed by chemotherapy. We describe this case because of the well-known association between breast cancer and thyroid disease, particularly of the autoimmune type, the causes of this being still unclear. Recent literature on this topic is reviewed, discussing the possible role of the Na +-l - symporter and anti-TPO antibodies.

Original languageEnglish
Pages (from-to)504-506
Number of pages3
Issue number5
Publication statusPublished - Sep 2004


  • Anti-TPO antibodies
  • Autoimmune thyroid disorders
  • Breast cancer
  • Graves' disease
  • Na -l symporter

ASJC Scopus subject areas

  • Cancer Research


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