Abstract
Colloid milium (CM) is a rare cutaneous condition characterized by translucent papules occurring on sun-exposed regions including the face, neck and dorsal aspects of the hands and back. Clinically, there are two variants of CM: an adult-onset type and a juvenile form. The juvenile form is inherited and presents before puberty. Probably this variant is because of an inherited susceptibility to ultraviolet (UV) light and can be transmitted as both autosomal recessive and autosomal dominant character. In this paper, we report an interesting case of adult CM in a transfused patient affected by β thalassaemia major. The association of CM with β thalassaemia, to our knowledge, has not been reported previously, in literature. Thus, this case represents the first case of CM associated with β thalassaemia major. In our view, the lesion could be related to excess iron, similar to pseudoxanthoma elastic-like lesions, another cutaneous disorder which is present in β thalassaemia. As our patient is a farmer and was exposed to sun during his work, UV light damage could have have a role in promoting the development of the disease. Other cases of CM associated with β thalassaemia should be reported to confirm these hypotheses.
| Original language | English |
|---|---|
| Pages (from-to) | 566-569 |
| Number of pages | 4 |
| Journal | Journal of Cutaneous Pathology |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2008 |
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ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
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A case of colloid milium in patient with β thalassaemia major. / Giordano, Giovanna; Ricci, Roberto; Froio, Elisabetta; Izzi, Giancarlo; Barone, Angelica; Boccaletti, Valeria.
In: Journal of Cutaneous Pathology, Vol. 35, No. 6, 06.2008, p. 566-569.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of colloid milium in patient with β thalassaemia major
AU - Giordano, Giovanna
AU - Ricci, Roberto
AU - Froio, Elisabetta
AU - Izzi, Giancarlo
AU - Barone, Angelica
AU - Boccaletti, Valeria
PY - 2008/6
Y1 - 2008/6
N2 - Colloid milium (CM) is a rare cutaneous condition characterized by translucent papules occurring on sun-exposed regions including the face, neck and dorsal aspects of the hands and back. Clinically, there are two variants of CM: an adult-onset type and a juvenile form. The juvenile form is inherited and presents before puberty. Probably this variant is because of an inherited susceptibility to ultraviolet (UV) light and can be transmitted as both autosomal recessive and autosomal dominant character. In this paper, we report an interesting case of adult CM in a transfused patient affected by β thalassaemia major. The association of CM with β thalassaemia, to our knowledge, has not been reported previously, in literature. Thus, this case represents the first case of CM associated with β thalassaemia major. In our view, the lesion could be related to excess iron, similar to pseudoxanthoma elastic-like lesions, another cutaneous disorder which is present in β thalassaemia. As our patient is a farmer and was exposed to sun during his work, UV light damage could have have a role in promoting the development of the disease. Other cases of CM associated with β thalassaemia should be reported to confirm these hypotheses.
AB - Colloid milium (CM) is a rare cutaneous condition characterized by translucent papules occurring on sun-exposed regions including the face, neck and dorsal aspects of the hands and back. Clinically, there are two variants of CM: an adult-onset type and a juvenile form. The juvenile form is inherited and presents before puberty. Probably this variant is because of an inherited susceptibility to ultraviolet (UV) light and can be transmitted as both autosomal recessive and autosomal dominant character. In this paper, we report an interesting case of adult CM in a transfused patient affected by β thalassaemia major. The association of CM with β thalassaemia, to our knowledge, has not been reported previously, in literature. Thus, this case represents the first case of CM associated with β thalassaemia major. In our view, the lesion could be related to excess iron, similar to pseudoxanthoma elastic-like lesions, another cutaneous disorder which is present in β thalassaemia. As our patient is a farmer and was exposed to sun during his work, UV light damage could have have a role in promoting the development of the disease. Other cases of CM associated with β thalassaemia should be reported to confirm these hypotheses.
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U2 - 10.1111/j.1600-0560.2007.00834.x
DO - 10.1111/j.1600-0560.2007.00834.x
M3 - Article
C2 - 18466363
AN - SCOPUS:43549121279
VL - 35
SP - 566
EP - 569
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 6
ER -