A case of "en bloc" excision of a chest wall leiomyosarcoma and closure of the defect with non-cross-linked collagen matrix (Egis®)

Marco Rastrelli, Saveria Tropea, Romina Spina, Alessandra Costa, Roberto Stramare, Simone Mocellin, Maria Giuseppina Bonavina, Carlo Riccardo Rossi

Research output: Contribution to journalArticle


Sarcomas arising from the chest wall account for less than 20% of all soft tissue sarcomas, and at this site, primitive tumors are the most frequent to occur. Leiomyosarcoma is a malignant smooth muscle tumor and the best outcomes are achieved with wide surgical excision. Although advancements have been made in treatment protocols, leiomyosarcoma remains one of the more difficult soft tissue sarcoma to treat. Currently, general local control is obtained with surgical treatment with wide negative margins. We describe the case of a 50-year-old man who underwent a chest wall resection involving a wide portion of the pectoralis major and minor muscle, the serratus and part of the second, third and fourth ribs of the left side. The full-thickness chest wall defect of 10 × 8 cm was closed using a non-cross-linked acellular dermal matrix (Egis®) placed in two layers, beneath the rib plane and over it. A successful repair was achieved with no incisional herniation and with complete tissue regeneration, allowing natural respiratory movements. No complications were observed in the postoperative course. Biological non-cross-linked matrix, derived from porcine dermis, behaves like a scaffold supporting tissue regeneration; it can be successfully used as an alternative to synthetic mesh for chest wall reconstruction.

Original languageEnglish
Pages (from-to)655-660
Number of pages6
JournalCase Reports in Oncology
Issue number3
Publication statusPublished - Sep 13 2016



  • Acellular dermis
  • Guided tissue regeneration
  • Leiomyosarcoma
  • Thoracic wall

ASJC Scopus subject areas

  • Oncology

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