A case of Guillain-Barré syndrome in a patient with non small cell lung cancer treated with chemotherapy

G. Cicero, F. Fulfaro, A. Caraceni, C. Arcara, G. Badalamenti, C. Intrivici, Nicola Gebbia

Research output: Contribution to journalArticlepeer-review

Abstract

Guillain-Barré Syndrome (GBS) is a demyelinating polyneuropathy of probable autoimmune pathogenesis characterized by rapidly progressive symmetric paralysis. In the literature some cases of GBS associated with anticancer chemotherapy are reported. We present a case of a 55-year old woman who complained of progressive motor deficit in four limbs, areflexia in lower limbs and facial nerve paralysis one week after beginning cisplatin-gemcitabine chemotherapy for metastatic lung cancer. The cerebrospinal fluid analysis showed a strong positive Pandy reaction with 435 mg/dl total protein. The electromyography and the electroneuronography established the diagnosis of inflammatory demyelinating polyneuropathy. Specific therapy with intravenous immunoglobulin 25 g/day in 5 administrations for 5 days was started with complete benefit.

Original languageEnglish
Pages (from-to)325-327
Number of pages3
JournalJournal of Chemotherapy
Volume18
Issue number3
Publication statusPublished - Jun 2006

Keywords

  • Chemotherapy toxicity
  • Guillain-Barré Syndrome
  • Lung cancer
  • Neuropathy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

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