Abstract
Guillain-Barré Syndrome (GBS) is a demyelinating polyneuropathy of probable autoimmune pathogenesis characterized by rapidly progressive symmetric paralysis. In the literature some cases of GBS associated with anticancer chemotherapy are reported. We present a case of a 55-year old woman who complained of progressive motor deficit in four limbs, areflexia in lower limbs and facial nerve paralysis one week after beginning cisplatin-gemcitabine chemotherapy for metastatic lung cancer. The cerebrospinal fluid analysis showed a strong positive Pandy reaction with 435 mg/dl total protein. The electromyography and the electroneuronography established the diagnosis of inflammatory demyelinating polyneuropathy. Specific therapy with intravenous immunoglobulin 25 g/day in 5 administrations for 5 days was started with complete benefit.
Original language | English |
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Pages (from-to) | 325-327 |
Number of pages | 3 |
Journal | Journal of Chemotherapy |
Volume | 18 |
Issue number | 3 |
Publication status | Published - Jun 2006 |
Keywords
- Chemotherapy toxicity
- Guillain-Barré Syndrome
- Lung cancer
- Neuropathy
ASJC Scopus subject areas
- Pharmacology (medical)
- Microbiology (medical)