Un caso di epatocarcinoma preceduto per anni da aumento "isolato" dell'alfafetoproteina.

Translated title of the contribution: A case of hepatocarcinoma preceded by several years by "isolated" increase in alphafetoprotein

M. Durazzo, E. Borghesio, D. Regge, P. A. Milone, M. Rizzetto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hepatocarcinoma (HCC), the most frequent malignant hepatic neoplasia, is sometimes difficult to diagnose at an early stage since the symptoms may be attributed to concomitant hepatic cirrhosis. The assay of alpha-fetoprotein associated with an ultrasound examination of the hepatic parenchyma is an important screening tool for high-risk patients. Ultrasound examination is considered the most sensitive method and alpha-fetoprotein is a supplementary diagnostic tool. Elevated alpha-fetoprotein only occasionally precedes morphological anomalies and even in these cases the neoplastic aspect emerges within a short period of time. The case reported here illustrates the "astronomic" increase of alpha-fetoprotein in a high-risk patient for HCC (positive HBsAg cirrhosis) without the manifest appearance of any instrumental or histological data confirming the presence of the tumour for two years. When the tumour was identified in instrumental tests it had spread throughout the entire hepatic parenchyma in a form which could no longer be treated using any form of therapy. The case reported here emphasizes the diagnostic value of alphafetoprotein in high-risk patients for HCC, even in the prolonged absence of all other data regarding neoplastic transformation.

Original languageItalian
Pages (from-to)167-169
Number of pages3
JournalMinerva Gastroenterologica e Dietologica
Volume38
Issue number3
Publication statusPublished - Jul 1992

Fingerprint

alpha-Fetoproteins
Liver
Neoplasms
Hepatitis B Surface Antigens
Liver Cirrhosis
Fibrosis
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Un caso di epatocarcinoma preceduto per anni da aumento "isolato" dell'alfafetoproteina. / Durazzo, M.; Borghesio, E.; Regge, D.; Milone, P. A.; Rizzetto, M.

In: Minerva Gastroenterologica e Dietologica, Vol. 38, No. 3, 07.1992, p. 167-169.

Research output: Contribution to journalArticle

Durazzo, M. ; Borghesio, E. ; Regge, D. ; Milone, P. A. ; Rizzetto, M. / Un caso di epatocarcinoma preceduto per anni da aumento "isolato" dell'alfafetoproteina. In: Minerva Gastroenterologica e Dietologica. 1992 ; Vol. 38, No. 3. pp. 167-169.
@article{d0bbf747406547feb27420a46bfc66dc,
title = "Un caso di epatocarcinoma preceduto per anni da aumento {"}isolato{"} dell'alfafetoproteina.",
abstract = "Hepatocarcinoma (HCC), the most frequent malignant hepatic neoplasia, is sometimes difficult to diagnose at an early stage since the symptoms may be attributed to concomitant hepatic cirrhosis. The assay of alpha-fetoprotein associated with an ultrasound examination of the hepatic parenchyma is an important screening tool for high-risk patients. Ultrasound examination is considered the most sensitive method and alpha-fetoprotein is a supplementary diagnostic tool. Elevated alpha-fetoprotein only occasionally precedes morphological anomalies and even in these cases the neoplastic aspect emerges within a short period of time. The case reported here illustrates the {"}astronomic{"} increase of alpha-fetoprotein in a high-risk patient for HCC (positive HBsAg cirrhosis) without the manifest appearance of any instrumental or histological data confirming the presence of the tumour for two years. When the tumour was identified in instrumental tests it had spread throughout the entire hepatic parenchyma in a form which could no longer be treated using any form of therapy. The case reported here emphasizes the diagnostic value of alphafetoprotein in high-risk patients for HCC, even in the prolonged absence of all other data regarding neoplastic transformation.",
author = "M. Durazzo and E. Borghesio and D. Regge and Milone, {P. A.} and M. Rizzetto",
year = "1992",
month = "7",
language = "Italian",
volume = "38",
pages = "167--169",
journal = "Minerva Gastroenterologica",
issn = "0026-4776",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "3",

}

TY - JOUR

T1 - Un caso di epatocarcinoma preceduto per anni da aumento "isolato" dell'alfafetoproteina.

AU - Durazzo, M.

AU - Borghesio, E.

AU - Regge, D.

AU - Milone, P. A.

AU - Rizzetto, M.

PY - 1992/7

Y1 - 1992/7

N2 - Hepatocarcinoma (HCC), the most frequent malignant hepatic neoplasia, is sometimes difficult to diagnose at an early stage since the symptoms may be attributed to concomitant hepatic cirrhosis. The assay of alpha-fetoprotein associated with an ultrasound examination of the hepatic parenchyma is an important screening tool for high-risk patients. Ultrasound examination is considered the most sensitive method and alpha-fetoprotein is a supplementary diagnostic tool. Elevated alpha-fetoprotein only occasionally precedes morphological anomalies and even in these cases the neoplastic aspect emerges within a short period of time. The case reported here illustrates the "astronomic" increase of alpha-fetoprotein in a high-risk patient for HCC (positive HBsAg cirrhosis) without the manifest appearance of any instrumental or histological data confirming the presence of the tumour for two years. When the tumour was identified in instrumental tests it had spread throughout the entire hepatic parenchyma in a form which could no longer be treated using any form of therapy. The case reported here emphasizes the diagnostic value of alphafetoprotein in high-risk patients for HCC, even in the prolonged absence of all other data regarding neoplastic transformation.

AB - Hepatocarcinoma (HCC), the most frequent malignant hepatic neoplasia, is sometimes difficult to diagnose at an early stage since the symptoms may be attributed to concomitant hepatic cirrhosis. The assay of alpha-fetoprotein associated with an ultrasound examination of the hepatic parenchyma is an important screening tool for high-risk patients. Ultrasound examination is considered the most sensitive method and alpha-fetoprotein is a supplementary diagnostic tool. Elevated alpha-fetoprotein only occasionally precedes morphological anomalies and even in these cases the neoplastic aspect emerges within a short period of time. The case reported here illustrates the "astronomic" increase of alpha-fetoprotein in a high-risk patient for HCC (positive HBsAg cirrhosis) without the manifest appearance of any instrumental or histological data confirming the presence of the tumour for two years. When the tumour was identified in instrumental tests it had spread throughout the entire hepatic parenchyma in a form which could no longer be treated using any form of therapy. The case reported here emphasizes the diagnostic value of alphafetoprotein in high-risk patients for HCC, even in the prolonged absence of all other data regarding neoplastic transformation.

UR - http://www.scopus.com/inward/record.url?scp=0026894985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026894985&partnerID=8YFLogxK

M3 - Articolo

C2 - 1284376

AN - SCOPUS:0026894985

VL - 38

SP - 167

EP - 169

JO - Minerva Gastroenterologica

JF - Minerva Gastroenterologica

SN - 0026-4776

IS - 3

ER -