A case of ischemic stroke in acute promyelocytic leukemia at initial presentation: Relevance of all-trans retinoic acid treatment

Angelo M. Carella, Giuseppe Antonucci, Matteo Conte, Michele Di Pumpo, Elisabetta Antonucci, Ernestina Ponziano

Research output: Contribution to journalArticlepeer-review

Abstract

Acute promyelocytic leukemia (APL) is frequently associated, often from the earliest phases, with a life-threatening coagulation/bleeding syndrome; disseminated intravascular coagulation (DIC) is described in majority of patients. We report a case of 49-year-old male, without cardiovascular risk factors, who suddenly developed ischemic stroke and splenic infarction as presenting symptoms of APL and related DIC. The patient was immediately treated with all-trans retinoic acid (ATRA) and the alterations of hemocoagulation parameters promptly returned in normal range. The coagulation/bleeding syndrome of the onset of APL is associated with high mortality; both diagnostic and therapeutic approaches require special and timely consideration of this condition. Treatment with ATRA is essential.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCardiovascular and Hematological Disorders - Drug Targets
Volume10
Issue number1
Publication statusPublished - Mar 2010

Keywords

  • Acute promyelocytic leukemia
  • All-trans retinoic acid
  • Disseminated intravascular coagulation
  • Ischemic stroke

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Hematology
  • Pharmacology

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