A case of late onset lipid storage myopathy: Electromyographic histochemical and ultrastructural findings

P. Pinelli; M. Poloni; G. Nappi; R. Scelsi

doi:10.1159/000114683

A case of late onset lipid storage myopathy: Electromyographic histochemical and ultrastructural findings

P. Pinelli, M. Poloni, G. Nappi, R. Scelsi

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

A 65-year-old woman showed the clinical picture of a myogenic myopathy, confirmed electromyographically. Detailed histopathological, histochemical and ultrastructural studies were performed on deltoid and quadriceps femoris biopsy specimens. Many muscle fibres were found to contain vacuolar spaces with lipid droplets: perivascular inflammatory changes were also observed. The affected fibres were consistently type I. Under the electron microscope the fibres contained large numbers of lipid droplets, usually next to normal mitochondria. A slight improvement occurred after prednisone therapy.

Original language	English
Pages (from-to)	273-284
Number of pages	12
Journal	European Neurology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1159/000114683
Publication status	Published - 1975

Keywords

Late onset myopathy
Lipid storage myopathy
Prednisone therapy
Type i fibre atrophy

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1159/000114683

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abstract = "A 65-year-old woman showed the clinical picture of a myogenic myopathy, confirmed electromyographically. Detailed histopathological, histochemical and ultrastructural studies were performed on deltoid and quadriceps femoris biopsy specimens. Many muscle fibres were found to contain vacuolar spaces with lipid droplets: perivascular inflammatory changes were also observed. The affected fibres were consistently type I. Under the electron microscope the fibres contained large numbers of lipid droplets, usually next to normal mitochondria. A slight improvement occurred after prednisone therapy.",

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AU - Scelsi, R.

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AB - A 65-year-old woman showed the clinical picture of a myogenic myopathy, confirmed electromyographically. Detailed histopathological, histochemical and ultrastructural studies were performed on deltoid and quadriceps femoris biopsy specimens. Many muscle fibres were found to contain vacuolar spaces with lipid droplets: perivascular inflammatory changes were also observed. The affected fibres were consistently type I. Under the electron microscope the fibres contained large numbers of lipid droplets, usually next to normal mitochondria. A slight improvement occurred after prednisone therapy.

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KW - Type i fibre atrophy

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A case of late onset lipid storage myopathy: Electromyographic histochemical and ultrastructural findings

Abstract

Keywords

ASJC Scopus subject areas

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