A case of manic episode during treatment with 5-fluorouracil, epirubicin and cyclophosphamide for breast cancer

Isabella Pacchiarotti, Lorenzo Mazzarini, Patrizia Pellegrini, Viola Venturelli, Gabriele Sani, José Sánchez-Moreno, Iginia Mancinelli, Roberto Tatarelli, Giorgio D. Kotzalidis, Paolo Girardi

Research output: Contribution to journalArticlepeer-review

Abstract

A 41-year-old woman with breast cancer developed a manic episode while being treated with a 5-fluorouracil-epirubicin-cyclophosphamide combination (most likely caused by the first drug). Chemotherapy was discontinued, and antipsychotic treatment with haloperidol and olanzapine was instituted. She recovered after 10 days. Normal computerized tomography (CT) scans and neurological examinations were consistent with the absence of neurological symptoms on physical exam.

Original languageEnglish
Pages (from-to)461-463
Number of pages3
JournalGeneral Hospital Psychiatry
Volume29
Issue number5
DOIs
Publication statusPublished - Nov 2007

Keywords

  • 5-Fluorouracil
  • Cyclophosphamide
  • Drug-induced
  • Epirubicin
  • Leukoencephalopathy
  • Manic episode

ASJC Scopus subject areas

  • Emergency Medicine
  • Medicine(all)
  • Psychiatry and Mental health

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