A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma

G. Simonetti; Paola Gaviani; E. Lamperti; A. Innocenti; A. Botturi; M. Saini; B. Pollo; A. Silvani

doi:10.1007/s10072-016-2640-8

A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma

G. Simonetti, Paola Gaviani, E. Lamperti, A. Innocenti, A. Botturi, M. Saini, B. Pollo, A. Silvani

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Neurological Sciences
DOIs	https://doi.org/10.1007/s10072-016-2640-8
Publication status	Published - 2016

Keywords

Genetic abnormalities
High-grade glioma
Medulloblastoma
Radiotherapy-induced tumors

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Dermatology

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10.1007/s10072-016-2640-8

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abstract = "Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.",

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AU - Simonetti, G.

AU - Gaviani, Paola

AU - Lamperti, E.

AU - Innocenti, A.

AU - Botturi, A.

AU - Saini, M.

AU - Pollo, B.

AU - Silvani, A.

PY - 2016

Y1 - 2016

N2 - Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.

AB - Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.

KW - Genetic abnormalities

KW - High-grade glioma

KW - Medulloblastoma

KW - Radiotherapy-induced tumors

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A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma

Abstract

Keywords

ASJC Scopus subject areas

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