TY - JOUR
T1 - A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma
AU - Simonetti, G.
AU - Gaviani, Paola
AU - Lamperti, E.
AU - Innocenti, A.
AU - Botturi, A.
AU - Saini, M.
AU - Pollo, B.
AU - Silvani, A.
PY - 2016
Y1 - 2016
N2 - Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.
AB - Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.
KW - Genetic abnormalities
KW - High-grade glioma
KW - Medulloblastoma
KW - Radiotherapy-induced tumors
UR - http://www.scopus.com/inward/record.url?scp=84975266390&partnerID=8YFLogxK
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U2 - 10.1007/s10072-016-2640-8
DO - 10.1007/s10072-016-2640-8
M3 - Article
AN - SCOPUS:84975266390
SP - 1
EP - 4
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
ER -