A case of melanotic desmoplastic ganglioglioma: Case Report

Manila Antonelli, Stefania Acerno, Cristina Baldoli, Maria Rosaria Terreni, Felice Giangaspero

Research output: Contribution to journalArticlepeer-review


We describe a case of desmoplastic infantile ganglioglioma (DIG) in a 9-month-old boy located in the temporal lobe. Grossly the tumor was brown and superficially located. Histologically the tumor contained pigment in numerous neoplastic cells, shown to be melanosomal melanin by ultrastructural examination. Pigmented neoplasms have been reported at various sites in the central and peripheral nervous system. Previous reports on pigmented neuroepithelial tumors include neoplasms containing melanin, while others have contained neuromelanin and or lipofuscin. This case represents the first description of pigmented neoplastic cells in DIG, enlarging the spectrum of pigmented primary CNS tumors.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
Issue number5
Publication statusPublished - Oct 2009


  • Infantile desmoplastic ganglioglioma
  • Lipofuscin
  • Melanosomal melanogenesis
  • Neuromelanin
  • Pigmented glioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology


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