A case of melanotic desmoplastic ganglioglioma: Case Report

Manila Antonelli; Stefania Acerno; Cristina Baldoli; Maria Rosaria Terreni; Felice Giangaspero

doi:10.1111/j.1440-1789.2009.01041.x

A case of melanotic desmoplastic ganglioglioma: Case Report

Manila Antonelli, Stefania Acerno, Cristina Baldoli, Maria Rosaria Terreni, Felice Giangaspero

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Abstract

We describe a case of desmoplastic infantile ganglioglioma (DIG) in a 9-month-old boy located in the temporal lobe. Grossly the tumor was brown and superficially located. Histologically the tumor contained pigment in numerous neoplastic cells, shown to be melanosomal melanin by ultrastructural examination. Pigmented neoplasms have been reported at various sites in the central and peripheral nervous system. Previous reports on pigmented neuroepithelial tumors include neoplasms containing melanin, while others have contained neuromelanin and or lipofuscin. This case represents the first description of pigmented neoplastic cells in DIG, enlarging the spectrum of pigmented primary CNS tumors.

Original language	English
Pages (from-to)	597-601
Number of pages	5
Journal	Neuropathology
Volume	29
Issue number	5
DOIs	https://doi.org/10.1111/j.1440-1789.2009.01041.x
Publication status	Published - Oct 2009

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Keywords

Infantile desmoplastic ganglioglioma
Lipofuscin
Melanosomal melanogenesis
Neuromelanin
Pigmented glioma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology

Cite this

Antonelli, M., Acerno, S., Baldoli, C., Terreni, M. R., & Giangaspero, F. (2009). A case of melanotic desmoplastic ganglioglioma: Case Report. Neuropathology, 29(5), 597-601. https://doi.org/10.1111/j.1440-1789.2009.01041.x

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10.1111/j.1440-1789.2009.01041.x