A case of metachronous double primary neuroendocrine cancer in pancreas/ileum and uterine cervix

Giovanni Sisti, Anna Maria Buccoliero, Luca Novelli, Maddalena Sansovini, Stefano Severi, Annalisa Pieralli, Lorenzo Livi, Massimiliano Fambrini

Research output: Contribution to journalArticlepeer-review

Abstract

We describe an unusual case of a 50-year-old female patient developing two primary cancers with neuroendocrine features. Initially the patient underwent surgery for an entero-pancreatic neuroendocrine carcinoma. During the subsequent follow-up she experienced some episodes of vaginal bleeding with negative PET scanning with the tracer fluorine-18 (F-18) fluorodeoxyglucose (FDG). A Papanicolaou (pap) smear and an endometrial biopsy revealed a primary neuroendocrine cancer of the uterine cervix. The present case underlines the importance of clinical follow-up after a diagnosis of intestinal neuroendocrine tumor, investigating any new symptom. Female patients, after the diagnosis of entero-pancreatic neuroendocrine carcinoma, must be recommended to continue screening pap test examinations for the likelihood of classical squamous and glandular cervical cancers and also for neuroendocrine cervical cancer.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalUpsala Journal of Medical Sciences
Volume117
Issue number4
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Metachronous double primary cancer
  • Neuroendocrine cancer
  • Pancreas
  • Pap smear
  • Uterine cervix

ASJC Scopus subject areas

  • Medicine(all)

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