Un caso di gammopatia monoclonale risolto grazie ai biomarcatori cardiaci

Translated title of the contribution: A case of monoclonal gammopathy solved with cardiac biomarkers

Research output: Contribution to journalArticle


Monoclonal gammopathy of undetermined significance (MGUS) is the most common plasma cell proliferative disorder, with a prevalence >3% in the general population older than 50 years. The prevalence of MGUS increases with age, from 1.7% in those 50 to 59 years old to >5% in those older than 70 years. MGUS is associated with an increased risk of multiple myeloma or related malignancies at a rate of 1% per year. Recently, it has been proposed to add the measurement of N-terminal B-type natriuretic peptide (NT-proBNP) to traditional tests used for monitoring MGUS to timely detect initial cardiac amyloid involvement. In this report, we present the case of a patient with MGUS who was followed at our center since February 2006. During the follow-up, the progressive increase of NT-proBNP and cardiac troponin I suggested the onset of primary systemic light-chain amyloidosis (AL) with cardiac involvement. The subsequent investigations led to the definition of the cause of heart dysfunction. This case highlights the importance of the regular follow-up of MGUS and the contribution of cardiac biomarkers in improving the clinical efficacy of monitoring.

Translated title of the contributionA case of monoclonal gammopathy solved with cardiac biomarkers
Original languageItalian
Pages (from-to)262-265
Number of pages4
JournalBiochimica Clinica
Issue number3
Publication statusPublished - Jun 2011

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology

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