A case of myokymia-cramp syndrome successfully treated with gabapentin

M. Serrao, P. Cardinali, P. Rossi, L. Parisi, R. Tramutoli, F. Pierelli

Research output: Contribution to journalArticlepeer-review


We report a case of 'myokymia-cramp syndrome', a rare and benign disease consisting of muscular cramps in the upper and lower limbs associated with generalized myokymias. In our patient, cramps had been present since adolescence and had increased in frequency and duration during the last 3 years, occurring about 8 or 9 times a day. Cramps were mainly nocturnal and also precipitated by walking; a previous treatment with carbamazepine did not improve the symptoms. Gabapentin therapy proved to be very satisfactory in relieving muscular cramps with a relatively low dosage (600 mg/day) and without any remarkable side effects. The possible interpretation of the mechanism involved in gabapentin induced relief of cramps is discussed. Gabapentin should be considered as a safe alternative treatment for muscular cramps.

Original languageEnglish
Pages (from-to)458-460
Number of pages3
JournalActa Neurologica Scandinavica
Issue number6
Publication statusPublished - 1998


  • Cramps
  • Gabapentin
  • Myokymia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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