A case of PANDAS treated with tetrabenazine and tonsillectomy

Francesca Romana Fusco, Alessandra Pompa, Giorgio Bernardi, Fabrizio Ottaviani, Carmela Giampà, Daunia Laurenti, Maria Morello, Sergio Bernardini, Marzia Nuccetelli, Umberto Sabatini, Stefano Paolucci

Research output: Contribution to journalArticlepeer-review


PANDAS (pediatric autoimmune neuropsychiatry disorders associated with streptococcal infections) is a rare clinical syndrome characterized by the presence of tics, Tourette syndrome, obsessive-compulsive disorder, or chorea in the context of an immediately precedent streptococcal infection. In this report, we describe the case of an 11-year-old boy who developed PANDAS with severe choreic movements. The criteria for PANDAS diagnosis were met. Moreover, serum antibrain antibodies were present. The patient was initially treated with tetrabenazine 12.5 mg twice daily with remission of the neurological symptoms. Subsequently, the patient underwent tonsillectomy and has been asymptomatic since, with antistreptolysin O titer levels in range.

Original languageEnglish
Pages (from-to)614-615
Number of pages2
JournalJournal of Child Neurology
Issue number5
Publication statusPublished - May 2010


  • Autoimmune disorders
  • Chorea
  • Tetrabenazine

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health


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