A case of paracoccidioidomycosis: Experience with long-term therapy

G. Borgia, L. Reynaud, R. Cerini, R. Ciampi, O. Schioppa, M. Dello Russo, I. Gentile, M. Piazza

Research output: Contribution to journalArticlepeer-review

Abstract

We describe long-term therapy for paracoccidioidomycosis occurring in a 61-year-old housepainter from Venezuela. The diagnostic examinations made in South America had shown pulmonary granulomatous lesions and an osteolytic pattern of the left knee that had been considered suspect of malignant disease with an indication for limb amputation. With the aid of fine needle aspiration biopsy (FNAB) and culture examination we diagnosed an osteomyelitis by Paracoccidioides brasiliensis and initiated therapy with itraconazole, 400 mg per day, reduced to 200 mg per day after 2 months. At the end of 2 years of drug therapy, we observed complete regression of the pulmonary lesions and of the osteolytic area of the left knee. Moreover, we have periodically observed our patient to verify his clinical development and he is still in good health. We suggest that this pathology be considered in differential diagnosis of leprosy, tuberculosis, leishmaniasis, and systemic mycoses, even in non-endemic areas.

Original languageEnglish
Pages (from-to)119-120
Number of pages2
JournalInfection
Volume28
Issue number2
DOIs
Publication statusPublished - 2000

Keywords

  • Itraconazole
  • Mycosis
  • Osteolysis
  • Paracoccidioidomycosis
  • Therapy of paracoccidioidomycosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Fingerprint Dive into the research topics of 'A case of paracoccidioidomycosis: Experience with long-term therapy'. Together they form a unique fingerprint.

Cite this