Abstract
We describe long-term therapy for paracoccidioidomycosis occurring in a 61-year-old housepainter from Venezuela. The diagnostic examinations made in South America had shown pulmonary granulomatous lesions and an osteolytic pattern of the left knee that had been considered suspect of malignant disease with an indication for limb amputation. With the aid of fine needle aspiration biopsy (FNAB) and culture examination we diagnosed an osteomyelitis by Paracoccidioides brasiliensis and initiated therapy with itraconazole, 400 mg per day, reduced to 200 mg per day after 2 months. At the end of 2 years of drug therapy, we observed complete regression of the pulmonary lesions and of the osteolytic area of the left knee. Moreover, we have periodically observed our patient to verify his clinical development and he is still in good health. We suggest that this pathology be considered in differential diagnosis of leprosy, tuberculosis, leishmaniasis, and systemic mycoses, even in non-endemic areas.
| Original language | English |
|---|---|
| Pages (from-to) | 119-120 |
| Number of pages | 2 |
| Journal | Infection |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Itraconazole
- Mycosis
- Osteolysis
- Paracoccidioidomycosis
- Therapy of paracoccidioidomycosis
ASJC Scopus subject areas
- Microbiology (medical)
- Immunology
Cite this
A case of paracoccidioidomycosis : Experience with long-term therapy. / Borgia, G.; Reynaud, L.; Cerini, R.; Ciampi, R.; Schioppa, O.; Dello Russo, M.; Gentile, I.; Piazza, M.
In: Infection, Vol. 28, No. 2, 2000, p. 119-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of paracoccidioidomycosis
T2 - Experience with long-term therapy
AU - Borgia, G.
AU - Reynaud, L.
AU - Cerini, R.
AU - Ciampi, R.
AU - Schioppa, O.
AU - Dello Russo, M.
AU - Gentile, I.
AU - Piazza, M.
PY - 2000
Y1 - 2000
N2 - We describe long-term therapy for paracoccidioidomycosis occurring in a 61-year-old housepainter from Venezuela. The diagnostic examinations made in South America had shown pulmonary granulomatous lesions and an osteolytic pattern of the left knee that had been considered suspect of malignant disease with an indication for limb amputation. With the aid of fine needle aspiration biopsy (FNAB) and culture examination we diagnosed an osteomyelitis by Paracoccidioides brasiliensis and initiated therapy with itraconazole, 400 mg per day, reduced to 200 mg per day after 2 months. At the end of 2 years of drug therapy, we observed complete regression of the pulmonary lesions and of the osteolytic area of the left knee. Moreover, we have periodically observed our patient to verify his clinical development and he is still in good health. We suggest that this pathology be considered in differential diagnosis of leprosy, tuberculosis, leishmaniasis, and systemic mycoses, even in non-endemic areas.
AB - We describe long-term therapy for paracoccidioidomycosis occurring in a 61-year-old housepainter from Venezuela. The diagnostic examinations made in South America had shown pulmonary granulomatous lesions and an osteolytic pattern of the left knee that had been considered suspect of malignant disease with an indication for limb amputation. With the aid of fine needle aspiration biopsy (FNAB) and culture examination we diagnosed an osteomyelitis by Paracoccidioides brasiliensis and initiated therapy with itraconazole, 400 mg per day, reduced to 200 mg per day after 2 months. At the end of 2 years of drug therapy, we observed complete regression of the pulmonary lesions and of the osteolytic area of the left knee. Moreover, we have periodically observed our patient to verify his clinical development and he is still in good health. We suggest that this pathology be considered in differential diagnosis of leprosy, tuberculosis, leishmaniasis, and systemic mycoses, even in non-endemic areas.
KW - Itraconazole
KW - Mycosis
KW - Osteolysis
KW - Paracoccidioidomycosis
KW - Therapy of paracoccidioidomycosis
UR - http://www.scopus.com/inward/record.url?scp=0034109542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034109542&partnerID=8YFLogxK
U2 - 10.1007/s150100050060
DO - 10.1007/s150100050060
M3 - Article
C2 - 10782401
AN - SCOPUS:0034109542
VL - 28
SP - 119
EP - 120
JO - Infection
JF - Infection
SN - 0300-8126
IS - 2
ER -