A case of persistent bacteraemia by Ralstonia mannitolilytica and Ralstonia pickettii in an intensive care unit

Monica Basso, Carolina Venditti, Giammarco Raponi, Anna Sara Navazio, Francesco Alessandri, Emanuela Giombini, Carla Nisii, Antonino Di Caro, Mario Venditti

Research output: Contribution to journalArticle


The Ralstonia spp. genus is a group of non-fermentative, Gram-negative bacteria often resistant to many antibiotics, which are emerging as opportunistic pathogens frequently associated with infections in hospital settings. We present herein a case of combined R. pickettii and R. mannitolilytica persisting and relapsing bacteraemia, possibly caused by a septic arterial thrombosis secondary to the rupture of an internal carotid artery aneurysm. Microbiology studies showed that both Ralstonia isolates produced biofilm and carried class D oxacillinase genes. When confronted with infections caused by members of the Ralstonia genus, identification to the species level is crucial for correct clinical management, as the two species show different antibiotic susceptibility patterns.

Original languageEnglish
Pages (from-to)2391-2395
Number of pages5
JournalInfection and Drug Resistance
Publication statusPublished - Jan 1 2019



  • Bacteraemia
  • Endovascular infection
  • Ralstonia mannitolilytica
  • Ralstonia pickettii

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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