Corticobasal degeneration (CBD) is a ncurodcgcnerative disease characteri/ed clinically by impairment of motor function with variable involvement of cognition. Language dysfunction is rarely observed, especially in the first stages of the disease. We icpon a 58 years om man uith progressive aphasia, who developed, after eighteen months from the onset of language disturbances, motor impairment highly suggestive of CBD. Asymmetric rigidity, bradikinesia, parkinsonian gait, alien limb phenomenon more evident on the left side, limb apraxia and stimulus sensitive myoclonus were present. At follow-up examination, after 6 months, misreaching and simultancoagnosia became also evident, together with a worsening of the cxtrapyramidal syndrome. Language disturbance was initially characterized by increasing word finding difficulty, hesitant speech, frequent literal paraphasias and errors in repetition, worsening to marked non-fluent aphasia in a 3 years course MR1 showed diffuse cerebral atrophy with marked narrowing of the corpus callosum Serial SPECT documented a significant hypoperfusion of the left thalamus and of the right temporoparietal cortex, suggesting that in this case aphasia may predominantly be due to left subcortical dysfunction, whereas the alien limb phenomenon could be related to the prevalent right posterior cortical impairment We discuss the neuropsychological presentation and evolution of this case.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology