A case of relapsed medulloblastoma treated with intensity-modulated radiotherapy and temozolomide

Maurizio Mascarin, Stefano Dall'Oglio, Mario Palazzi, Giovanna Sartor, Pier Luigi Marradi, Mario Romano, Sergio Maluta

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Abstract

We report a case of relapsed high-risk non-metastatic medulloblastoma in a 14-year-old boy, which was treated with intensity-modulated radiotherapy (IMRT) and temozolomide (TMZ). At the age of 11, the patient underwent an MRI-confirmed incomplete resection of a fourth-ventricle medulloblastoma, followed by conventional chemotherapy, craniospinal irradiation (55.8 Gy, 1.8 Gy/fraction) and then myeloablative chemotherapy followed by peripheral blood progenitor cell rescue. After 18 months of complete remission following the completion of chemotherapy, MRI showed a 2.5-cmmass in the olfactory notch. The patient underwent IMRT (45 Gy, 1.8 Gy/fraction) with concomitant administration of TMZ (180 mg/m 2, 5 days every 21 days), which was well tolerated. After 5 cycles of TMZ, MRI showed complete remission with no evidence of the mass. TMZ was continued for another 5 cycles and then stopped. At 14 months from the completion of IMRT, a new MRI scan showed multiple nodular relapses around the fourth ventricle and the patient is currently treated with oral etoposide.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalTumori
Volume96
Issue number2
Publication statusPublished - Mar 2010

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Keywords

  • High-risk medulloblastoma
  • IMRT
  • Relapse
  • Temozolomide

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mascarin, M., Dall'Oglio, S., Palazzi, M., Sartor, G., Marradi, P. L., Romano, M., & Maluta, S. (2010). A case of relapsed medulloblastoma treated with intensity-modulated radiotherapy and temozolomide. Tumori, 96(2), 327-331.