A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib

Giacomo Gotti, Veronica Biassoni, Elisabetta Schiavello, Filippo Spreafico, Manila Antonelli, Giuseppina Calareso, Emilia Pecori, Lorenza Gandola, Maura Massimino

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction:: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation:: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion:: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.

Original languageEnglish
Pages (from-to)1621-1623
Number of pages3
JournalChild's Nervous System
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 10 2015

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Celecoxib
Cyclophosphamide
Drug Therapy
Radiotherapy
Nervous System Neoplasms
Therapeutics
Central Nervous System
Recurrence
Atypical Teratoid Tumor
Typical Teratoid Rhabdoid Tumor
vinorelbine

Keywords

  • Atypical teratoid/rhabdoid tumor
  • Metronomic chemotherapy
  • Spinal tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib. / Gotti, Giacomo; Biassoni, Veronica; Schiavello, Elisabetta; Spreafico, Filippo; Antonelli, Manila; Calareso, Giuseppina; Pecori, Emilia; Gandola, Lorenza; Massimino, Maura.

In: Child's Nervous System, Vol. 31, No. 9, 10.09.2015, p. 1621-1623.

Research output: Contribution to journalArticle

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