Abstract
Introduction:: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation:: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion:: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 1621-1623 |
| Number of pages | 3 |
| Journal | Child's Nervous System |
| Volume | 31 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 10 2015 |
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Keywords
- Atypical teratoid/rhabdoid tumor
- Metronomic chemotherapy
- Spinal tumor
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology
Cite this
A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib. / Gotti, Giacomo; Biassoni, Veronica; Schiavello, Elisabetta; Spreafico, Filippo; Antonelli, Manila; Calareso, Giuseppina; Pecori, Emilia; Gandola, Lorenza; Massimino, Maura.
In: Child's Nervous System, Vol. 31, No. 9, 10.09.2015, p. 1621-1623.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib
AU - Gotti, Giacomo
AU - Biassoni, Veronica
AU - Schiavello, Elisabetta
AU - Spreafico, Filippo
AU - Antonelli, Manila
AU - Calareso, Giuseppina
AU - Pecori, Emilia
AU - Gandola, Lorenza
AU - Massimino, Maura
PY - 2015/9/10
Y1 - 2015/9/10
N2 - Introduction:: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation:: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion:: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
AB - Introduction:: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation:: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion:: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
KW - Atypical teratoid/rhabdoid tumor
KW - Metronomic chemotherapy
KW - Spinal tumor
UR - http://www.scopus.com/inward/record.url?scp=84941188987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941188987&partnerID=8YFLogxK
U2 - 10.1007/s00381-015-2755-x
DO - 10.1007/s00381-015-2755-x
M3 - Article
C2 - 26008576
AN - SCOPUS:84941188987
VL - 31
SP - 1621
EP - 1623
JO - Child's Nervous System
JF - Child's Nervous System
SN - 0256-7040
IS - 9
ER -