TY - JOUR
T1 - A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib
AU - Gotti, Giacomo
AU - Biassoni, Veronica
AU - Schiavello, Elisabetta
AU - Spreafico, Filippo
AU - Antonelli, Manila
AU - Calareso, Giuseppina
AU - Pecori, Emilia
AU - Gandola, Lorenza
AU - Massimino, Maura
PY - 2015/9/10
Y1 - 2015/9/10
N2 - Introduction:: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation:: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion:: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
AB - Introduction:: Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis. Case presentation:: The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis. Conclusion:: The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
KW - Atypical teratoid/rhabdoid tumor
KW - Metronomic chemotherapy
KW - Spinal tumor
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U2 - 10.1007/s00381-015-2755-x
DO - 10.1007/s00381-015-2755-x
M3 - Article
C2 - 26008576
AN - SCOPUS:84941188987
VL - 31
SP - 1621
EP - 1623
JO - Child's Nervous System
JF - Child's Nervous System
SN - 0256-7040
IS - 9
ER -