A case of treatment-resistant bipolar depression and comorbid OCD treated with deep brain stimulation of the medial forebrain bundle: 5 years follow-up results

Lucio Oldani, Beatrice Benatti, Monica Macellaro, Mauro Porta, Domenico Servello, Edvin Zekaj, Bernardo Dell'Osso

Research output: Contribution to journalArticlepeer-review

Abstract

Limited though promising evidence exists on the efficacy of Deep Brain Stimulation (DBS) of the Medial Forebrain Bundle (MFB) in otherwise intractable patients with Major Depression and Obsessive-Compulsive Disorder (OCD). Herein, we present acute and follow-up results (up to 5 years) of a 42 year old man with a diagnosis of treatment-resistant Bipolar Depression (BD) and comorbid OCD, successfully treated with DBS of the MFB. Regular follow-up visits with psychometric evaluations highlighted a considerable improvement of patient's depressive and OC symptoms at 5 years from implant. According to the limited, reported experience, we support the efficacy and tolerability of DBS of the MFB as a promising intervention in patients with treatment-resistant BD and comorbid OCD, with specific emphasis on the long-term outcome.

Original languageEnglish
Pages (from-to)103-105
Number of pages3
JournalJournal of Clinical Neuroscience
Volume89
DOIs
Publication statusPublished - Jul 2021

Keywords

  • Deep brain stimulation (DBS)
  • Medial forebrain bundle (MFB)
  • Treatment resistant depression
  • Treatment resistant obsessive–compulsive disorder

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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