A case of vacuolar myopathy during the course of chronic hepatitis C

Stefano Zoccolella, Luigi Serlenga, Angela Amati, Vito Lavolpe, Nicola Minerva, Mohammed Agremorz, Antonio Toscano, Paolo Lamberti

Research output: Contribution to journalArticlepeer-review


Several cases of inflammatory myopathy have been reported during the chronic course of hepatitis C (HC) in recent years. It has been suggested that this muscular inflammatory involvement in HC is related to an immune-mediated mechanism caused by the hepatitis C virus (HCV), as HCV RNA has been detected in the muscle of patients with concomitant inflammatory myopathy and chronic HC. Herein, we report on a patient with a history of chronic HC, who developed a slowly progressive proximal muscle weakness; muscle biospy revealed a vacuolar myopathy. Histological, immunohistochemical and biochemical study did not disclose any known cause of vacuolar myopathy. To our knowledge, this is the first report of a vacuolar myopathy during the course of HC. We suggest that it may be opportune to include HC among the possible aetiologies of vacuolar myopathy, should other reports confirm this association.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalFunctional Neurology
Issue number3
Publication statusPublished - Jul 2006


  • Chronic hepatitis
  • Hepatitis C virus
  • Vacuolar myopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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