A case of vacuolar myopathy during the course of chronic hepatitis C

Stefano Zoccolella, Luigi Serlenga, Angela Amati, Vito Lavolpe, Nicola Minerva, Mohammed Agremorz, Antonio Toscano, Paolo Lamberti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several cases of inflammatory myopathy have been reported during the chronic course of hepatitis C (HC) in recent years. It has been suggested that this muscular inflammatory involvement in HC is related to an immune-mediated mechanism caused by the hepatitis C virus (HCV), as HCV RNA has been detected in the muscle of patients with concomitant inflammatory myopathy and chronic HC. Herein, we report on a patient with a history of chronic HC, who developed a slowly progressive proximal muscle weakness; muscle biospy revealed a vacuolar myopathy. Histological, immunohistochemical and biochemical study did not disclose any known cause of vacuolar myopathy. To our knowledge, this is the first report of a vacuolar myopathy during the course of HC. We suggest that it may be opportune to include HC among the possible aetiologies of vacuolar myopathy, should other reports confirm this association.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalFunctional Neurology
Volume21
Issue number3
Publication statusPublished - Jul 2006

Fingerprint

Chronic Hepatitis C
Hepatitis C
Myositis
Hepacivirus
Muscles
Muscle Weakness
RNA
Vacuolar myopathy

Keywords

  • Chronic hepatitis
  • Hepatitis C virus
  • Vacuolar myopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Zoccolella, S., Serlenga, L., Amati, A., Lavolpe, V., Minerva, N., Agremorz, M., ... Lamberti, P. (2006). A case of vacuolar myopathy during the course of chronic hepatitis C. Functional Neurology, 21(3), 169-171.

A case of vacuolar myopathy during the course of chronic hepatitis C. / Zoccolella, Stefano; Serlenga, Luigi; Amati, Angela; Lavolpe, Vito; Minerva, Nicola; Agremorz, Mohammed; Toscano, Antonio; Lamberti, Paolo.

In: Functional Neurology, Vol. 21, No. 3, 07.2006, p. 169-171.

Research output: Contribution to journalArticle

Zoccolella, S, Serlenga, L, Amati, A, Lavolpe, V, Minerva, N, Agremorz, M, Toscano, A & Lamberti, P 2006, 'A case of vacuolar myopathy during the course of chronic hepatitis C', Functional Neurology, vol. 21, no. 3, pp. 169-171.
Zoccolella S, Serlenga L, Amati A, Lavolpe V, Minerva N, Agremorz M et al. A case of vacuolar myopathy during the course of chronic hepatitis C. Functional Neurology. 2006 Jul;21(3):169-171.
Zoccolella, Stefano ; Serlenga, Luigi ; Amati, Angela ; Lavolpe, Vito ; Minerva, Nicola ; Agremorz, Mohammed ; Toscano, Antonio ; Lamberti, Paolo. / A case of vacuolar myopathy during the course of chronic hepatitis C. In: Functional Neurology. 2006 ; Vol. 21, No. 3. pp. 169-171.
@article{e2b16b21794641b185c7fab3e470c60a,
title = "A case of vacuolar myopathy during the course of chronic hepatitis C",
abstract = "Several cases of inflammatory myopathy have been reported during the chronic course of hepatitis C (HC) in recent years. It has been suggested that this muscular inflammatory involvement in HC is related to an immune-mediated mechanism caused by the hepatitis C virus (HCV), as HCV RNA has been detected in the muscle of patients with concomitant inflammatory myopathy and chronic HC. Herein, we report on a patient with a history of chronic HC, who developed a slowly progressive proximal muscle weakness; muscle biospy revealed a vacuolar myopathy. Histological, immunohistochemical and biochemical study did not disclose any known cause of vacuolar myopathy. To our knowledge, this is the first report of a vacuolar myopathy during the course of HC. We suggest that it may be opportune to include HC among the possible aetiologies of vacuolar myopathy, should other reports confirm this association.",
keywords = "Chronic hepatitis, Hepatitis C virus, Vacuolar myopathy",
author = "Stefano Zoccolella and Luigi Serlenga and Angela Amati and Vito Lavolpe and Nicola Minerva and Mohammed Agremorz and Antonio Toscano and Paolo Lamberti",
year = "2006",
month = "7",
language = "English",
volume = "21",
pages = "169--171",
journal = "Functional Neurology",
issn = "0393-5264",
publisher = "CIC Edizioni Internazionali s.r.l.",
number = "3",

}

TY - JOUR

T1 - A case of vacuolar myopathy during the course of chronic hepatitis C

AU - Zoccolella, Stefano

AU - Serlenga, Luigi

AU - Amati, Angela

AU - Lavolpe, Vito

AU - Minerva, Nicola

AU - Agremorz, Mohammed

AU - Toscano, Antonio

AU - Lamberti, Paolo

PY - 2006/7

Y1 - 2006/7

N2 - Several cases of inflammatory myopathy have been reported during the chronic course of hepatitis C (HC) in recent years. It has been suggested that this muscular inflammatory involvement in HC is related to an immune-mediated mechanism caused by the hepatitis C virus (HCV), as HCV RNA has been detected in the muscle of patients with concomitant inflammatory myopathy and chronic HC. Herein, we report on a patient with a history of chronic HC, who developed a slowly progressive proximal muscle weakness; muscle biospy revealed a vacuolar myopathy. Histological, immunohistochemical and biochemical study did not disclose any known cause of vacuolar myopathy. To our knowledge, this is the first report of a vacuolar myopathy during the course of HC. We suggest that it may be opportune to include HC among the possible aetiologies of vacuolar myopathy, should other reports confirm this association.

AB - Several cases of inflammatory myopathy have been reported during the chronic course of hepatitis C (HC) in recent years. It has been suggested that this muscular inflammatory involvement in HC is related to an immune-mediated mechanism caused by the hepatitis C virus (HCV), as HCV RNA has been detected in the muscle of patients with concomitant inflammatory myopathy and chronic HC. Herein, we report on a patient with a history of chronic HC, who developed a slowly progressive proximal muscle weakness; muscle biospy revealed a vacuolar myopathy. Histological, immunohistochemical and biochemical study did not disclose any known cause of vacuolar myopathy. To our knowledge, this is the first report of a vacuolar myopathy during the course of HC. We suggest that it may be opportune to include HC among the possible aetiologies of vacuolar myopathy, should other reports confirm this association.

KW - Chronic hepatitis

KW - Hepatitis C virus

KW - Vacuolar myopathy

UR - http://www.scopus.com/inward/record.url?scp=37849189309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37849189309&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:37849189309

VL - 21

SP - 169

EP - 171

JO - Functional Neurology

JF - Functional Neurology

SN - 0393-5264

IS - 3

ER -