A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: A new entity or a combined tumour?

Fausto Maffini; Daniele Lorenzini; Daniela Lepanto; Elvio De Fiori; Caterina Fumagalli; Alessandra Rappa; Marta Tagliabue; Massimo Barberis

doi:10.3332/ecancer.2019.965

A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: A new entity or a combined tumour?

Fausto Maffini, Daniele Lorenzini, Daniela Lepanto, Elvio De Fiori, Caterina Fumagalli, Alessandra Rappa, Marta Tagliabue, Massimo Barberis

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning.

Original language	English
Article number	965
Journal	ecancermedicalscience
Volume	13
DOIs	https://doi.org/10.3332/ecancer.2019.965
Publication status	Published - Oct 2 2019

Keywords

BRAF
Mutation
Pathology
RET
Thyroid carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

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A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation : A new entity or a combined tumour? / Maffini, Fausto; Lorenzini, Daniele; Lepanto, Daniela ; De Fiori, Elvio ; Fumagalli, Caterina ; Rappa, Alessandra ; Tagliabue, Marta ; Barberis, Massimo.

In: ecancermedicalscience, Vol. 13, 965, 02.10.2019.

Research output: Contribution to journal › Article › peer-review

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abstract = "Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning.",

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AB - Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning.

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A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: A new entity or a combined tumour?

Abstract

Keywords

ASJC Scopus subject areas

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