A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: A new entity or a combined tumour?

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Abstract

Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning.

Original languageEnglish
Article number965
Journalecancermedicalscience
Volume13
DOIs
Publication statusPublished - Oct 2 2019

Keywords

  • BRAF
  • Mutation
  • Pathology
  • RET
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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