A case report of esophageal actinomycosis in an immunocompetent patient and review of the literature

Valeria Palmitessa, Renato Cuppone, Rosa Monno, Luciana Fumarola, Antonio Lippolis

Research output: Contribution to journalArticle


Actinomycosis is a rare, chronic and slowly progressive granulomatous disease caused by Actinomyces spp., a Gram-positive anaerobic bacterium that rarely affects the esophagus. Although this infection is uncommon, it has been reported in both immunocompromised and immunocompetent individuals. The infection is often misdiagnosed because it can mimic other pathological conditions (like neoplasms and candidiasis), and Actinomyces is difficult to isolate because it requires specific growth conditions. However, actinomycosis has a favorable course if the microbiological diagnosis is timely. We report a case of esophageal actinomycosis in an immunocompetent 23-year-old man. The patient was admitted with symptoms of gastro-esophageal reflux disease (GERD), that had subsequently worsened. Histological and microbiological investigations revealed the presence of Actinomyces spp. A review of the literature regarding the clinical features, diagnosis, and management of this infection is also discussed.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalThe new microbiologica
Issue number1
Publication statusPublished - Jan 2019


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