A case report on crossed aphasia in dextrals. Consideration about clinical features and neural network

Michele Torrisi, Patrizia Pollicino, Francesco Corallo, Giuliana Vermiglio, Anna Lisa Logiudice, Carmela Mantarro, Cinzia Calabrò, Placido Bramanti, Rocco Salvatore Calabrò, Rosa Morabito, Silvia Marino

Research output: Contribution to journalArticlepeer-review


Rationale:The term crossed aphasia in dextrals (CAD) describes aphasia following a right hemisphere lesion in right-handed subjects. The diagnostic criteria for CAD, defined on the basis of clinical cases observed over the years, are aphasia; lesion in right hemisphere; strong preference for right hand use without familial history of left handedness; structural integrity of left hemisphere; and absence of brain damage in childhood. The studies of CAD have mainly been focused on the neurobiological mechanisms underlying the functional neurocognitive lateralization and organization of the brain, such as a dissociation between language and handedness, language and praxis, or other cognitive functions.Patient concerns: We described a case of a patient affected by an aphasic syndrome following cerebral hemorrhage located in right hemisphere.Diagnosis: Considering the correlation between clinical data and instrumental investigations such as magnetic resonance imaging, we diagnose the patient with non-fluent aphasia. Specifically, the patient came to our attention showing a trans-cortical mixed aphasia that, later, developed in a trans-cortical motor aphasia. Contrary to most cases of CAD, our patient does not show apraxia and visuo-spatial neglect. Interventions language and visual attention when latter functions are related to right hemisphere.Interventions:The rehabilitation program consisted in exercises stimulating verbal fluency, comprehension, reading, and writing.Outcomes:After 5 months of rehabilitation patient showed significant improvement in comprehension and absence of echolalia.Lessons:At present there is no agreement about pathogenesis of CAD and neural mechanism is still unclear. Considering the clinical symptomatology, we can argue that we observed a non-fluent aphasia. However, a more large sample should be studied to asses the role of brain circuits.

Original languageEnglish
Article numbere17660
JournalMedicine (United States)
Issue number43
Publication statusPublished - Oct 1 2019


  • crossed aphasia
  • right hemisphere
  • stroke

ASJC Scopus subject areas

  • Medicine(all)


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